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Active Recombinant Mouse Interleukin 1 Receptor, Type I, Fc-tagged
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Cat.No. : | Il1r1-5651M Optional Service: Optional requirements on this protein |
Product Overview : | RecombinantMouse Il1r1 protein was expressed in Spodopterafrugiperdawith the Fc part of Human IgG1 Pro100-Lys330 (C-terminus) and MouseIl1r1 Phe14-Glu355 (N-terminus). |
Description : | Twodistinct types of receptors that bind the pleiotropic cytokines IL-1α andIL-1β have been described. The Il1r1 is an 80 kDa transmembrane protein thatis expressed predominantly by T cells, fibroblasts, and endothelialcells. IL-1receptor type II is a 68 kDa transmembrane protein found on B lymphocytes, neutrophils,monocytes, large granular leukocytes and endothelial cells. Both receptorsare members of the immunoglobulin superfamily and show approximately 28% sequencesimilarity in their extracellular domains. The two receptor types do not heterodimerizein a receptor complex. |
Source : | Spodopterafrugiperda, Sf 21 (baculovirus)-derived. |
Form : | Lyophilizedfrom a 0.2 um filtered solution in PBS. |
N-terminalSequence : | Phe14 |
MolecularWeight : | 64.7 kDa (monomer) |
Activity : | Measuredby its ability to inhibit IL-1α-dependent proliferation in D10.G4.1 mousehelper T cells. Approximately 2-8 μg/mL of IL-1 RII will inhibit 50% of thebiological response due to 50 pg/mL of recombinant mouse IL-1α. |
Endotoxin Level : | <1.0EU per 1μg of the protein by the LAL method. |
SDS-PAGE : | 70-80kDa, reducing conditions. |
Purity : | >95%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | 500 μg/mLin sterile PBS |
Storage : | Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3months, -20 to -70°C under sterile conditions after reconstitution. |
PDBrendering based on 1g0y. : |
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Gene Name : | Il1r1 interleukin 1 receptor,type I [ Mus musculus ] |
Official Symbol : | Il1r1 |
Synonyms : | Il1r1; interleukin 1receptor, type I; IL-iR; CD121a;CD121b; Il1r-1; interleukin-1 receptor type 1; p80; IL-1R-1; IL-1RT1;IL-1RT-1; IL-1R-alpha; IL-1 receptor alpha chain; interleukin-1 receptoralpha; interleukin-1 receptor type I; CD121 antigen-like family member A |
Gene ID : | 16177 |
mRNA Refseq : | NM_001123382 |
Protein Refseq : | NP_001116854 |
UniProt ID : | Q4FK69 |
Chromosome Location : | 1 |
Pathway : | Amoebiasis;Apoptosis; Cytokine-cytokine receptor interaction; HTLV-I infection;Hematopoietic cell lineage; Hypertrophy Model; IL-1 Signaling Pathway; MAPKsignaling pathway; Osteoclast differentiation |
Function : | interleukin-1receptor activity; interleukin-1, Type I, activating receptor activity;ionotropic glutamate receptor binding; platelet-derived growth factorreceptor binding; protease binding; protein binding; receptor activity;signal transducer activity; transmembrane signaling receptor activity |
◆ Recombinant Protein
IL1R1-164H | Recombinant Human IL1R1 Protein (ECD), His-tagged(C-ter) | +Inquiry |
Il1r1-883R | Recombinant Rat Il1r1 protein, His-tagged | +Inquiry |
IL1R1-214H | Active Recombinant Human IL1R1 Protein | +Inquiry |
Il1r1-882R | Recombinant Rat Il1r1 protein, His-tagged | +Inquiry |
Il1r1-5188M | Recombinant Mouse Il1r1, His tagged | +Inquiry |
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◆ Lysates
IL1R1-1120HCL | Recombinant Human IL1R1 cell lysate | +Inquiry |
IL1R1-945CCL | Recombinant Cynomolgus IL1R1 cell lysate | +Inquiry |
IL1R1-1935RCL | Recombinant Rat IL1R1 cell lysate | +Inquiry |
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IL10IL10RAIL10RBIL11IL11RAIl11ra1IL12IL12AIL12BIL12RB1IL13IL13RA1IL13RA2IL15IL15RAIL16IL17AIL17BIl17cIL17DIl17fIL17RAIL17RDIL18IL18BPIL18R1IL18RAPIl19Il1aIl1bIL1F10IL1R1Il1r2IL1RAPIL1RAPL1IL1RAPL2IL1RL1IL1RL2Il1rnIL2Il20IL20RAIL21IL21RIL22IL22BPIL22RA1IL22RA2IL23AIL24Il25IL27IL27RAIL28AIl28bIL29IL2RAIL2RBIl2rgIL3IL31IL32Il33Il34IL3RAIL4IL4RIl4raIl5IL5RAIl6IL6RIl6raIL6STIl7IL7RIL8IL9IL36AIl12rb2IL17RBIL23RIL26IL31RAIL36BIL36GIL36RNIL37IL9RIL17RCIL17REIL28RAIL4I1IL20RBIL17RELIl11ra2IL27bIL7RAIl23a&Il12b
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