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Official Full Name interleukin 24
Background This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms IL24; interleukin 24; ST16; interleukin-24; C49A; FISP; IL 4 induced secreted protein; IL 24; IL10B; mda 7; melanoma differentiation association protein 7; Mob 5; suppression of tumorigenicity 16 (melanoma differentiation); melanocyte-associated Mda-7; IL
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Human Cells
    • Mammalian Cell
    • NS0
    • S.cerevisiae
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • MIgG1 Fc
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL24-151H Recombinant Human IL24 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human IL24-14189H Recombinant Human IL24, GST-tagged E.coli GST
    Human IL24-1922HCL Recombinant Human IL24 cell lysate Human Cell N/A
    Human IL24-1925H Recombinant Human IL24 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IL24-276H Recombinant Human Interleukin 24 S.cerevisiae N/A
    Human IL24-380H Recombinant Human IL24, His tagged Human Cell His
    Human IL24-5211H Recombinant Human IL24 Protein, GST-tagged Wheat Germ GST
    Human IL24-553H Recombinant Human IL24 Protein (Met1-Leu207), MIgG1 Fc-tagged HEK293 MIgG1 Fc
    Human IL24-584H Recombinant Human IL24, MIgG2a Fc-tagged CHO Fc
    Human IL24-585H Recombinant Human IL24, HIgG1 Fc-tagged, mutant CHO Fc
    Human IL24-586H Recombinant Human IL24, HIgG1 Fc-tagged CHO Fc
    Human IL24-589H Recombinant Human IL24 protein, His-tagged E.coli His
    Human IL24-934H Recombinant Human IL24 Protein, His-tagged CHO His
    Mouse Il24-3517M Recombinant Mouse Il24 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Il24-796M Recombinant Mouse Il24 NS0 N/A
    Mouse IL24-8158M Recombinant Mouse IL24 Protein Mammalian Cell His
    Rat Il24-194R Recombinant Rat Il24 Protein, His/GST-tagged E.coli His/GST
    Rat IL24-3042R Recombinant Rat IL24 Protein Mammalian Cell His
    Rat Il24-30R Recombinant Rat Il24 protein, His-tagged E.coli His

    il24 involved in several pathways and played different roles in them. We selected most pathways il24 participated on our site, such as Cytokine-cytokine receptor interaction, IL23-mediated signaling events, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with il24 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IFNPHI3; CSH; IFNAR1; IL11RA2; IL8L2; IL1R2; TNFSF9; CD70; CCL3; BMPR1AB
    IL23-mediated signaling events IL24; IL23R; IL17F
    Jak-STAT signaling pathway AKT3A; IRX1; CCND2; PIAS1; LIF; IL17D; IFNA6; IL21R; PRLRA; IL21R.1
    Senescence and Autophagy IGFBP7; SLC39A1; COL10A1; MAP1LC3B; ING2; GABARAPL2; UVRAG; ING1; GABARAP; IGFBP5

    il24 has several biochemical functions, for example, cytokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by il24 itself. We selected most functions il24 had, and list some proteins which have the same functions with il24. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity CCL20A.3; IL34; HMGB1A; IFNA13; Ifnz; ADIPOQ; IFNA7; IFNA12; Il23a; Il12b; BMP2
    protein binding EEF1E1; AKAP8L; C10orf62; KLF3; KDR; FOXC2; MYBPH; IRF5; ABCB1; JAK1

    il24 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with il24 here. Most of them are supplied by our site. Hope this information will be useful for your research of il24.


    Xu, J; Mo, YW; et al. Conditionally replicative adenovirus-based mda-7/IL-24 expression enhances sensitivity of colon cancer cells to 5-fluorouracil and doxorubicin. JOURNAL OF GASTROENTEROLOGY 48:203-213(2013).
    Bakshi, S; Zhang, X; et al. Transcriptome analyses in normal prostate epithelial cells exposed to low-dose cadmium: Oncogenic and immunomodulations involving the action of tumor necrosis factor. ENVIRONMENTAL HEALTH PERSPECTIVES 116:769-776(2008).


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