• Official Full Name

    interleukin 24

  • Background

    This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
  • Synonyms

    IL24; interleukin 24; ST16; interleukin-24; C49A; FISP; IL 4 induced secreted protein; IL 24; IL10B; mda 7; melanoma differentiation association protein 7; Mob 5; suppression of tumorigenicity 16 (melanoma differentiation); melanocyte-associated Mda-7; IL;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Human Cells
    • Mammalian Cell
    • Mammalian cells
    • S.cerevisiae
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • His (Fc)
    • Avi
    • His(C
    • ter)
    • His|GST
    • MIgG1 Fc
    • Myc
    • DDK
    • Myc|DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL24-151H Recombinant Human IL24 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human IL24-585H Active Recombinant Human IL24, HIgG1 Fc-tagged, mutant CHO Fc
    Human IL24-14189H Recombinant Human IL24, GST-tagged E.coli GST
    Human IL24-1922HCL Recombinant Human IL24 cell lysate Human Cell N/A
    Human IL24-1314H Recombinant Human IL24 protein, His-tagged HEK293 His
    Human IL24-380H Recombinant Human IL24 protein, His-tagged HEK293 His
    Human IL24-276H Recombinant Human Interleukin 24 S.cerevisiae N/A
    Human IL24-586H Active Recombinant Human IL24, HIgG1 Fc-tagged CHO Fc
    Human IL24-510H Recombinant Human IL24 Protein
    Human IL24-584H Active Recombinant Human IL24, MIgG2a Fc-tagged CHO Fc
    Human IL24-934H Recombinant Human IL24 Protein, His-tagged CHO His
    Human IL24-589H Recombinant Human IL24 protein, His-tagged E.coli His
    Human IL24-5211H Recombinant Human IL24 Protein, GST-tagged Wheat Germ GST
    Human IL24-553H Recombinant Human IL24 Protein (Met1-Leu207), MIgG1 Fc-tagged HEK293 MIgG1 Fc
    Human IL24-1925H Recombinant Human IL24 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IL24-2978H Recombinant Human IL24 protein, His-tagged E.coli His
    Human IL24-180H Recombinant Active Human IL24 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Mouse Il24-3517M Recombinant Mouse Il24 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Il24-10583M Recombinant Mouse Il24 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse Il24-01M Active Recombinant Mouse Il24 Protein, His-Tagged E.coli His
    Mouse Il24-10583M-B Recombinant Mouse Il24 Protein Pre-coupled Magnetic Beads HEK293
    Mouse Il24-181M Recombinant Active Mouse IL24 Protein, His-tagged(C-ter) E.coli His(C-ter)
    Mouse Il24-796M Active Recombinant Mouse Il24 Mammalian cells N/A
    Mouse IL24-8158M Recombinant Mouse IL24 Protein Mammalian Cell His
    Rat Il24-194R Recombinant Rat Il24 Protein, His/GST-tagged E.coli His/GST
    Rat Il24-30R Recombinant Rat Il24 protein, His-tagged E.coli His
    Rat IL24-2697R-B Recombinant Rat IL24 Protein Pre-coupled Magnetic Beads HEK293
    Rat IL24-3042R Recombinant Rat IL24 Protein Mammalian Cell His
    Rat IL24-2697R Recombinant Rat IL24 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL24 Related Articles
    • IL24 Related Gene Family
    • IL24 Related Research Area

    IL24 involved in several pathways and played different roles in them. We selected most pathways IL24 participated on our site, such as Cytokine-cytokine receptor interaction, IL23-mediated signaling events, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL24 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionLEP;IL6;BMPR1BB;CNTFR;IL29;OSM;XCL1;GM13304;IFNG
    IL23-mediated signaling eventsIL23R;IL24;IL17F
    Jak-STAT signaling pathwayIL27RA;IFNB;HRAS;FHL1A;AKT2;IL15RA;AOX3;RNF207B;CSH
    Senescence and AutophagyING1;SLC39A1;RSL1D1;GABARAPL2;COL10A1;IGFBP5;ATG7;SLC39A2;SLC39A3

    IL24 has several biochemical functions, for example, cytokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL24 itself. We selected most functions IL24 had, and list some proteins which have the same functions with IL24. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activityIl1f8;IL36A;FLT3LG;LFT1;IL36RN;INHBAA;BMP8A;IL17A;GDF1
    protein bindingCCNT1;MAGEA8;MSI2;GLP1R;PLG;AGGF1;MET;SEC23B;THOP1

    IL24 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL24 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL24.


    Xu, J; Mo, YW; et al. Conditionally replicative adenovirus-based mda-7/IL-24 expression enhances sensitivity of colon cancer cells to 5-fluorouracil and doxorubicin. JOURNAL OF GASTROENTEROLOGY 48:203-213(2013).
    Bakshi, S; Zhang, X; et al. Transcriptome analyses in normal prostate epithelial cells exposed to low-dose cadmium: Oncogenic and immunomodulations involving the action of tumor necrosis factor. ENVIRONMENTAL HEALTH PERSPECTIVES 116:769-776(2008).
    • Q&As
    • Reviews

    Q&As (6)

    Ask a question
    Are there side effects of Il24? 12/31/2022

    The current study shows that the side effects of Il24 are relatively small, and mainly reflected in local reactions, allergic reactions, etc.

    Is Il24 safer and more effective than other treatments? 05/22/2022

    The safety and efficacy of Il24 need to be validated through more clinical studies, and the safety and efficacy of specific applications need to be evaluated based on individual patient differences.

    Which molecules does Il24 interact with? 07/18/2021

    Il24 interacts with IL20 receptor complex, IL22 protein, etc.

    How does Il24 interfere with the immune system? 08/31/2020

    It mainly regulates or interferes with the relevant processes of the immune system by inhibiting some mediators secreted by immune cells, such as cytokines and chemokines.

    What are the advantages of Il24 application? 02/27/2020

    Il24 has good biological activity, stability and repeatability, and can be large-scale produced by genetic engineering technology, which has potential drug development and application prospects.

    Can recombinant Il24 be used to treat tumors? 09/29/2019

    Yes, Il24 has been shown to treat many types of solid tumors, including brain glioma, melanoma, lung cancer, prostate cancer, and more.

    Customer Reviews (3)

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      Cell experiments are used to evaluate the biological activity of the remade proteins. For example, functional experiments such as cell proliferation, migration, or apoptosis can be used to detect the effects of the proteins on the cells. -


        The expression of specific antigens in cells is detected by western blotting. -


          Mass spectrometry techniques can be used to determine the molecular weight and composition of proteins. -

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