IL24
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Official Full Name
interleukin 24
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Background
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. -
Synonyms
IL24; interleukin 24; ST16; interleukin-24; C49A; FISP; IL 4 induced secreted protein; IL 24; IL10B; mda 7; melanoma differentiation association protein 7; Mob 5; suppression of tumorigenicity 16 (melanoma differentiation); melanocyte-associated Mda-7; IL;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL24 Related Articles
- IL24 Related Gene Family
- IL24 Related Research Area
IL24 involved in several pathways and played different roles in them. We selected most pathways IL24 participated on our site, such as Cytokine-cytokine receptor interaction, IL23-mediated signaling events, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL24 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | LEP;IL6;BMPR1BB;CNTFR;IL29;OSM;XCL1;GM13304;IFNG |
| IL23-mediated signaling events | IL23R;IL24;IL17F |
| Jak-STAT signaling pathway | IL27RA;IFNB;HRAS;FHL1A;AKT2;IL15RA;AOX3;RNF207B;CSH |
| Senescence and Autophagy | ING1;SLC39A1;RSL1D1;GABARAPL2;COL10A1;IGFBP5;ATG7;SLC39A2;SLC39A3 |
IL24 has several biochemical functions, for example, cytokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL24 itself. We selected most functions IL24 had, and list some proteins which have the same functions with IL24. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | Il1f8;IL36A;FLT3LG;LFT1;IL36RN;INHBAA;BMP8A;IL17A;GDF1 |
| protein binding | CCNT1;MAGEA8;MSI2;GLP1R;PLG;AGGF1;MET;SEC23B;THOP1 |
IL24 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL24 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL24.
CHEK2; PARP1; RAD51; ATM; HMMR; BAG4; HRAS; KRAS; RARG; APC; AKT1; LSP1; PIK3CA; CCR5; PTEN
- Q&As
- Reviews
Q&As (6)
Ask a questionThe current study shows that the side effects of Il24 are relatively small, and mainly reflected in local reactions, allergic reactions, etc.
The safety and efficacy of Il24 need to be validated through more clinical studies, and the safety and efficacy of specific applications need to be evaluated based on individual patient differences.
Il24 interacts with IL20 receptor complex, IL22 protein, etc.
It mainly regulates or interferes with the relevant processes of the immune system by inhibiting some mediators secreted by immune cells, such as cytokines and chemokines.
Il24 has good biological activity, stability and repeatability, and can be large-scale produced by genetic engineering technology, which has potential drug development and application prospects.
Yes, Il24 has been shown to treat many types of solid tumors, including brain glioma, melanoma, lung cancer, prostate cancer, and more.
Customer Reviews (3)
Write a reviewCell experiments are used to evaluate the biological activity of the remade proteins. For example, functional experiments such as cell proliferation, migration, or apoptosis can be used to detect the effects of the proteins on the cells. -
The expression of specific antigens in cells is detected by western blotting. -
Mass spectrometry techniques can be used to determine the molecular weight and composition of proteins. -
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