Recombinant Human IL6ST Protein, His-tagged

• Cat.No.: IL6ST-1055H
• Product Overview: Recombinant Human IL6ST Protein (Thr392-Leu566) with His tag was expressed in 293F.

Specification

• Description: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17.
• Source: HEK293F
• Species: Human
• Tag: N-His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 20.6 kDa; Accurate Molecular Mass: 31-48 kDa
• Protein length: Thr392-Leu566
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) [ Homo sapiens (human) ]
• Official Symbol: IL6ST
• Synonyms: IL6ST; interleukin 6 signal transducer (gp130, oncostatin M receptor); interleukin-6 receptor subunit beta; CD130; GP130; CD130 antigen; IL-6R subunit beta; membrane glycoprotein 130; IL-6 receptor subunit beta; membrane glycoprotein gp130; interleukin receptor beta chain; oncostatin-M receptor subunit alpha; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; CDW130; IL-6RB; DKFZp564F053
• Gene ID: 3572
• mRNA Refseq: NM_001190981
• Protein Refseq: NP_001177910
• MIM: 600694
• UniProt ID: P40189

Reviews

02/28/2022

IL6ST proteins can be functionally enhanced or altered by protein modification techniques.

08/04/2020

As an immunotherapy drug, it has good effect and high safety.

09/06/2019

Has a good inhibitory effect on cell proliferation and survival.

Q&As

How to detect IL6ST activity?

The activity of IL6ST is usually detected by cell differentiation and proliferation assay.

In what diseases does IL6ST have applications?

IL6ST may be used in the future to treat pulmonary fibrosis, chronic pulmonary obstruction, rheumatoid arthritis, and other chronic kidney diseases.

Are there any effects of IL6ST on cell differentiation?

IL6ST is involved in various inflammatory responses and cell differentiation processes.

What are the physical and chemical properties of IL6ST?

The physical and chemical properties of IL6ST include molecular weight, voltammetry potential, structure and stability.

Why research IL6ST?

The study of IL6ST helps us to better understand the disease mechanism involved in IL6ST, and provides new ideas and means for disease treatment.

What is the preparation method of IL6ST?

The IL6ST is usually prepared by transforming E. coli into an expression vector and making it express the IL6ST protein.