Recombinant Human IL6ST Protein, GST-tagged
Cat.No. : | IL6ST-5171H |
Product Overview : | Human IL6ST partial ORF ( NP_002175, 23 a.a. - 122 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 36.74 kDa |
AA Sequence : | ELLDPCGYISPESPVVQLHSNFTAV CVLKEKCMDYFHVNANYIVWKTNHF TIPKEQYTIINRTASSVTFTDIASL NIQLTCNILTFGQLEQNVYGITIIS |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) [ Homo sapiens ] |
Official Symbol : | IL6ST |
Synonyms : | IL6ST; interleukin 6 signal transducer (gp130, oncostatin M receptor); interleukin-6 receptor subunit beta; CD130; GP130; CD130 antigen; IL-6R subunit beta; membrane glycoprotein 130; IL-6 receptor subunit beta; membrane glycoprotein gp130; interleukin receptor beta chain; oncostatin-M receptor subunit alpha; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; CDW130; IL-6RB; DKFZp564F053; |
Gene ID : | 3572 |
mRNA Refseq : | NM_001190981 |
Protein Refseq : | NP_001177910 |
MIM : | 600694 |
UniProt ID : | P40189 |
Products Types
◆ Recombinant Protein | ||
IL6ST-2750H | Recombinant Human IL6ST protein(691-860 aa), C-His-tagged | +Inquiry |
IL6ST-2749H | Recombinant Human IL6ST protein(771-910 aa), C-His-tagged | +Inquiry |
IL6ST-225H | Recombinant Human IL6ST Protein, His (Fc)-Avi-tagged | +Inquiry |
Il6st-26R | Recombinant Rat Il6st Protein, His (Fc)-Avi-tagged | +Inquiry |
IL6ST-2076R | Recombinant Rhesus Macaque IL6ST Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
IL6ST-946CCL | Recombinant Cynomolgus IL6ST cell lysate | +Inquiry |
IL6ST-001MCL | Recombinant Mouse IL6ST cell lysate | +Inquiry |
IL6ST-1882RCL | Recombinant Rat IL6ST cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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- Reviews
Q&As (6)
Ask a questionThe activity of IL6ST is usually detected by cell differentiation and proliferation assay.
IL6ST may be used in the future to treat pulmonary fibrosis, chronic pulmonary obstruction, rheumatoid arthritis, and other chronic kidney diseases.
IL6ST is involved in various inflammatory responses and cell differentiation processes.
The physical and chemical properties of IL6ST include molecular weight, voltammetry potential, structure and stability.
The study of IL6ST helps us to better understand the disease mechanism involved in IL6ST, and provides new ideas and means for disease treatment.
The IL6ST is usually prepared by transforming E. coli into an expression vector and making it express the IL6ST protein.
Customer Reviews (3)
Write a reviewIL6ST proteins can be functionally enhanced or altered by protein modification techniques.
As an immunotherapy drug, it has good effect and high safety.
Has a good inhibitory effect on cell proliferation and survival.
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