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Recombinant Human IL6ST Protein, GST-tagged

Cat.No. : IL6ST-5171H
Product Overview : Human IL6ST partial ORF ( NP_002175, 23 a.a. - 122 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 36.74 kDa
AA Sequence : ELLDPCGYISPESPVVQLHSNFTAV CVLKEKCMDYFHVNANYIVWKTNHF TIPKEQYTIINRTASSVTFTDIASL NIQLTCNILTFGQLEQNVYGITIIS
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) [ Homo sapiens ]
Official Symbol : IL6ST
Synonyms : IL6ST; interleukin 6 signal transducer (gp130, oncostatin M receptor); interleukin-6 receptor subunit beta; CD130; GP130; CD130 antigen; IL-6R subunit beta; membrane glycoprotein 130; IL-6 receptor subunit beta; membrane glycoprotein gp130; interleukin receptor beta chain; oncostatin-M receptor subunit alpha; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; CDW130; IL-6RB; DKFZp564F053;
Gene ID : 3572
mRNA Refseq : NM_001190981
Protein Refseq : NP_001177910
MIM : 600694
UniProt ID : P40189

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How to detect IL6ST activity? 04/26/2022

The activity of IL6ST is usually detected by cell differentiation and proliferation assay.

In what diseases does IL6ST have applications? 04/20/2021

IL6ST may be used in the future to treat pulmonary fibrosis, chronic pulmonary obstruction, rheumatoid arthritis, and other chronic kidney diseases.

Are there any effects of IL6ST on cell differentiation? 04/15/2021

IL6ST is involved in various inflammatory responses and cell differentiation processes.

What are the physical and chemical properties of IL6ST? 02/03/2021

The physical and chemical properties of IL6ST include molecular weight, voltammetry potential, structure and stability.

Why research IL6ST? 02/09/2019

The study of IL6ST helps us to better understand the disease mechanism involved in IL6ST, and provides new ideas and means for disease treatment.

What is the preparation method of IL6ST? 01/27/2019

The IL6ST is usually prepared by transforming E. coli into an expression vector and making it express the IL6ST protein.

Customer Reviews (3)

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Reviews
02/28/2022

    IL6ST proteins can be functionally enhanced or altered by protein modification techniques.

    08/04/2020

      As an immunotherapy drug, it has good effect and high safety.

      09/06/2019

        Has a good inhibitory effect on cell proliferation and survival.

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