Active Recombinant Mouse Il6st Homodimer Protein, His tagged

• Cat.No.: Il6st-48M
• Product Overview: Mouse IL-6Rb protein dimer contains an IL-6Rb extracellular domain (UniProt# Q00560) fused with a proprietary cis-dimer motif followed by a His tag at the C-terminus was expressed in HEK293T.

Specification

• Species: Mouse
• Source: HEK293T
• Tag: His
• Protein Length: 23-617 aa
• Description: Interleukin-6 receptor subunit beta (IL-6Rb) is a transmembrane protein and a member of the class of tall cytokine receptors. IL-6Rb is also known as Interleukin 6 Cytokine Family Signal Transducer (IL6ST), Cluster of Differentiation 130 (CD130), CDW130, and glycoprotein 130 (gp130). IL-6Rb serves as a shared signal transducing subunit of the receptor complexes for mouse cytokines, including interleukin-6 (IL-6), that mediate highly diverse biological processes. IL-6Rb can form homodimers and heterodimers with other cytokine receptors (i.e., IL-6 receptor alpha (IL-6Ra)) in response to cytokine binding. The homodimerization or heterodimerization of IL-6Rb is key to initiating intracellular signaling pathways. The extracellular domain of IL-6Rb includes an N-terminal immunoglobulin-like (Ig-like) domain (D1), a cytokine-binding homology region (CHR, D2D3), and three membrane-proximal fibronectin type III domains (FNIII, D4 to D6) followed by a transmembrane domain and cytoplasmic domain. It has been found that dysregulation of IL-6Rb expression and signaling mediates progression for multiple types of cancer and autoimmune diseases. Mouse IL-6Rb, the murine homolog of human IL-6Rb with conserved structural domains, is a species-specific tool essential for basic research, translational research and preclinical studies.
• Molecular Mass: 149 kDa
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for IL-6Rb-specific antibody binding assays. Suggested Applications: SPR & BLI for IL-6Rb-specific antibody binding assays. Animal immunization, RUO.
• Storage: Store at -80 centigrade.
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene Name: Il6st interleukin 6 signal transducer [ Mus musculus (house mouse) ]
• Official Symbol: Il6st
• Synonyms: Il6st; interleukin 6 signal transducer; CD130; gp130; D13Ertd699e; 5133400A03Rik; interleukin-6 receptor subunit beta; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; membrane glycoprotein 130; oncostatin-M receptor subunit alpha
• Gene ID: 16195
• mRNA Refseq: NM_010560
• Protein Refseq: NP_034690
• UniProt ID: Q00560