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Recombinant Mouse Interleukin 6 Signal Transducer, Fc-His

Cat.No. : Il6st-1743M
Product Overview : Recombinant Mouse Il6st encoding the extracellular domain of the gp130 protein sequence was fused to the carboxy-terminal 6X his-tagged Fc region of human IgG1 via a linker peptide, inserted into a suitable mammalian expression vector and expressed inNSO Cells.
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Cat. No. : Il6st-1743M
Description : Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of tall cytokine receptors. It forms one subunit of type I cytokine receptors within the IL-6 receptor family. It is often referred to as the common gp130 subunit, and is important for signal transduction following cytokine engagement. Gp130 signals are mediated by tyrosine kinases of the JAK family and by their binding partners, transcription factors of the STAT family. Gp130 signaling is very important for osteoblast function and calcium homeostasis.
Molecular Weight : The predicted molecular weight of Recombinant Mouse gp130 is Mr 94 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 130 kDa.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >90% by SDS Page and analyzed by silver stain.
Endotoxin : <0.1 EU/µg as determined by the LAL method.
Biological Activity : The biological activity of Mouse gp130 was determined by by its ability to inhibit the IL-6 sR enhancement of IL-6 activity on a mouse myeloid leukemia cell line, M1 (Saito, T. et al., 1991, J. Immunol. 147:168). The expected ED50 for this effect is typically 0.03-0.10 mg/mL in the presence of 10 ng/mL rhIL-6 sR and 20 ng/mL rhIL-6.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°Cto -70°C. After aseptic reconstitution, this protein may be stored at 2°Cto 8°Cfor one month or at -20°Cto -70°Cin a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : Il6st interleukin 6 signal transducer [ Mus musculus ]
Synonyms : Il6st; interleukin 6 signal transducer; CD130; gp130; AA389424; BB405851; D13Ertd699e; 5133400A03Rik
Gene ID : 16195
mRNA Refseq : NM_010560
Protein Refseq : NP_034690
UniProt ID : Q00560
Chromosome Location : 13 D2.2; 13 67.0 cM
Pathway : Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway
Function : cytokine receptor activity; interleukin-11 binding; interleukin-11 receptor activity; protein binding; receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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How to detect IL6ST activity? 04/26/2022

The activity of IL6ST is usually detected by cell differentiation and proliferation assay.

In what diseases does IL6ST have applications? 04/20/2021

IL6ST may be used in the future to treat pulmonary fibrosis, chronic pulmonary obstruction, rheumatoid arthritis, and other chronic kidney diseases.

Are there any effects of IL6ST on cell differentiation? 04/15/2021

IL6ST is involved in various inflammatory responses and cell differentiation processes.

What are the physical and chemical properties of IL6ST? 02/03/2021

The physical and chemical properties of IL6ST include molecular weight, voltammetry potential, structure and stability.

Why research IL6ST? 02/09/2019

The study of IL6ST helps us to better understand the disease mechanism involved in IL6ST, and provides new ideas and means for disease treatment.

What is the preparation method of IL6ST? 01/27/2019

The IL6ST is usually prepared by transforming E. coli into an expression vector and making it express the IL6ST protein.

Customer Reviews (3)

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Reviews
02/28/2022

    IL6ST proteins can be functionally enhanced or altered by protein modification techniques.

    08/04/2020

      As an immunotherapy drug, it has good effect and high safety.

      09/06/2019

        Has a good inhibitory effect on cell proliferation and survival.

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