Active Recombinant Human IL6ST Protein, His&Avi tagged

• Cat.No.: IL6ST-69H
• Product Overview: CD117 dimer protein contains a CD117 extracellular domain (UniProt# P10721) fused with a proprietary dimer motif followed by a tandem His-Avi tag at the C-terminus.

Specification

• Species: Human
• Source: HEK293T
• Tag: Avi&His
• Protein Length: 23-619 aa
• Description: Human glycoprotein 130 (gp130), is a transmembrane protein and a member of the class of tall cytokine receptors. Gp130 is also known as Interleukin 6 Cytokine Family Signal Transducer (IL6ST), Cluster of Differentiation 130 (CD130), CDW130, and Interleukin-6 Receptor Subunit Beta (IL6Rb). Gp130 serves as a shared signal transducing subunit of the receptor complexes for at least nine human cytokines including: interleukin-6 (IL-6), interleukin-11 (IL-11), interleukin-27 (IL-27), leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), cardiotrophin-1 (CT-1), cardiotrophin-like cytokine (CLC/CLCF-1), and neuropoietin (NP) that mediate highly diverse biological processes. Gp130 can form homodimers and heterodimers with other cytokine receptors (i.e., IL-6 receptor alpha (IL-6Ra)) in response to cytokine binding. The homodimerization or heterodimerization of gp130 is key to initiating intracellular signaling pathways, resulting in the activation of gp130-associated JAKs (JAK1, JAK2, and TYK2). The extracellular domain of gp130 includes an N-terminal immunoglobulin-like (Ig-like) domain (D1), a cytokine-binding homology region (CHR, D2D3), and three membrane-proximal fibronectin type III domains (FNIII, D4 to D6) followed by a transmembrane domain and cytoplasmic domain. It has been found that dysregulation of gp130 expression and signaling mediates progression for multiple types of cancer and autoimmune diseases. Inhibition of gp130 activity offers a potential and promising approach to cancer and autoimmune disease therapy.
• Molecular Mass: 156 kDa
• Homodimer/Heterodimer: Homodimer
• Purity: Greater than 90% dimer form as determined by SDS-PAGE under non-reducing condition
• Application: Verified Applications: ELISA for gp130-specific antibody and interleukin-6 (IL-6) ligand protein binding assays. Suggested Applications: ELISA for gp130-specific antibody and interleukin-6 (IL-6) ligand protein binding assays. SPR & BLI for gp130-specific antibody and IL-6 protein binding assays. Animal immunization, RUO.
• Storage: At -80 centigrade
• Storage Buffer: 0.22μm filtered PBS, pH 7.4
• Shipping: Frozen Dry Ice

Gene Information

• Gene ID: 3572
• Gene Name: IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) [Homo sapiens (human)]
• Official Symbol: IL6ST
• Synonyms: IL6ST; interleukin 6 signal transducer (gp130, oncostatin M receptor); interleukin-6 receptor subunit beta; CD130; GP130; CD130 antigen; IL-6R subunit beta; membrane glycoprotein 130; IL-6 receptor subunit beta; membrane glycoprotein gp130; interleukin receptor beta chain; oncostatin-M receptor subunit alpha; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; CDW130; IL-6RB; DKFZp564F053
• mRNA Refseq: NM_001190981
• Protein Refseq: NP_001177910
• MIM: 600694
• UniProt ID: P40189