ITGA4

  • Official Full Name

    integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

  • Overview

    The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.
  • Synonyms

    ITGA4; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor); IA4; CD49D;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITGA4-1541H Recombinant Human ITGA4 protein, His-tagged E.coli His
Human ITGA4-161H Recombinant Human ITGA4 & ITGB1, Flag & His tagged Human Cell His
Human ITGA4-5133HCL Recombinant Human ITGA4 293 Cell Lysate HEK293 N/A
Human ITGA4-4998H Recombinant Human ITGA4 Protein Wheat Germ N/A
Human ITGA4-4997H Recombinant Human ITGA4 Protein, GST-tagged Wheat Germ GST
Human ITGA4 & ITGB1-162H Active Recombinant Human ITGA4 & ITGB1 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human ITGA4 & ITGB7-890H Recombinant Human ITGA4 & ITGB7 protein, His-Avi-tagged HEK293 His-Avi
Human ITGA4-1210H Recombinant Human ITGA4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ITGA4 & ITGB7-163H Recombinant Human ITGA4 & ITGB7 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human ITGA4-3169H Recombinant Human ITGA4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ITGA4 & ITGB1-906H Recombinant Human ITGA4 & ITGB1 protein, His-Avi-tagged HEK293 His-Avi
Human ITGA4-4319H Recombinant Human ITGA4 Protein (Met1-Thr977), C-His tagged Mammalian cells C-His
Human ITGA4-2340H Recombinant Human ITGA4 Protein, His-tagged E.coli N-His
Human ITGA4-5707HF Recombinant Full Length Human ITGA4 Protein In Vitro Cell Free System
Human ITGA4-664HFL Recombinant Full Length Human ITGA4 Protein, C-Flag-tagged Mammalian cells Flag
Human ITGA4-1210H-B Recombinant Human ITGA4 Protein Pre-coupled Magnetic Beads HEK293
Mouse Itga4&Itgb1-347M Active Recombinant Mouse Itga4&Itgb1 CHO N/A
Mouse Itga4-5665M Active Recombinant Mouse Integrin Alpha 4, His-tagged CHO His
Mouse ITGA4-8350M Recombinant Mouse ITGA4 Protein Mammalian Cell His
Mouse Itga4-3595M Recombinant Mouse Itga4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Itga4-1696M Recombinant Mouse Itga4 Protein, His-tagged E.coli N-His
Mouse ITGA4-4637M Recombinant Mouse ITGA4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ITGA4-4637M-B Recombinant Mouse ITGA4 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ITGA4 Related Articles
  • ITGA4 Related Research Area

ITGA4 involved in several pathways and played different roles in them. We selected most pathways ITGA4 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PIK-Akt signaling pathwayINS;IL2RG;ITGA9;NRAS;RPS6KB1;TCL1;G6PC2;VTN;LAMA3
Focal adhesionRAC1;DIAPH1;PARVG;GRB2;PDGFRA;RHOAD;PARVAA;PPP1CBL;HRAS
ECM-receptor interactionITGB5;ITGA6;LAMC1;VTNB;ITGB8;COL27A1A;ITGA3;COL6A1;COL4A2
Cell adhesion molecules (CAMs)Siglec1;CLDN18;ITGB8;HLA-DRB3;ITGA9;ITGB1B.2;SDC4;HLA-G;VTCN1
Hematopoietic cell lineageIL5;CD8B1;IL6;Cd24a;ITGA6;ITGA2B;CD1B;CD59A;CD7
Leukocyte transendothelial migrationCLDN11;RHOA;NOX1;PIK3R3;CLDN6;RAC1;CYBA;RHOH;ITGB1
Intestinal iTNFRSF13B;HLA-DPB1;HLA-DMB;CXCR4B;H2-AA;CXCR4A;CD80;TNFSF13;MHC2DCB
ne network for IgA productionMHC2DCB;MHC2A;TNFRSF13B;ICOSLG;HLA-DQA2;MHC2DEB;TGFB1A;CCL28;CD28
Regulation of actin cytoskeletonPTK2;CYFIP2;ITGA7;ARPC5L;ARPC5A;ITGAM;RRAS2;ITGB1A;GSNA
LeishmaniasisMAPK1;PTGS2;HLA-DQB1;MAPK11;HLA-DOB;MAPK12;IFNGR2;IL4;TGFB1
Hypertrophic cardiomyopathy (HCM)IGF1;CACNB4;TPM2;ITGA2B;CACNA2D3;DMD;ITGA4;ACTB;TGFB2
Arrhythmogenic right ventricular cardiomyopathy (ARVC)ACTN4;EMD;JUP;ITGAV;CACNG6;CACNA2D1;SGCA;Itga10&Itgb1;CACNG8
Dilated cardiomyopathyITGB7;CACNG3;ITGB6;SLC8A1;PRKACG;CACNG2;CACNA2D1;DES;ITGA1

ITGA4 has several biochemical functions, for example, cell adhesion molecule binding, fibronectin binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA4 itself. We selected most functions ITGA4 had, and list some proteins which have the same functions with ITGA4. You can find most of the proteins on our site.

Function Related Protein
cell adhesion molecule bindingPVRL4;PVRL1B;CADM1;NLGN2;POSTN;PVR;Fert2;MSN;NRXN1
fibronectin bindingVEGFA;FSTL3;ITGB1;FBLN1;CTSS;SDC4;LPA;MYOC;ITGA4
metal ion bindingZFP36L1B;ZFP641;ZNF728;ZNF280A;DGKE;MMP13A;ZBED3;REPIN1;ZC3H15
protein antigen bindingEP300;KLRD1;H2-AB1;ITGA4;KLRC2
protein bindingLIN37;TEX10;HTR1E;HEMGN;CLCF1;APOD;GATA3;MTAP;CHPF

ITGA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA4.

PXN; ITGB1; VCAM1; LYN; TGFB1I1; LPXN; ITGB1; FLNA

Ullah, M; Sittinger, M; et al. Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units. MATRIX BIOLOGY 32:452-465(2013).
Reindel, R; Baker, SC; et al. Integrins alpha 4 and alpha M, collagen1A1, and matrix metalloproteinase 7 are upregulated in acute Kawasaki disease vasculopathy. PEDIATRIC RESEARCH 73:332-336(2013).
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