L1CAM

  • Official Full Name

    L1 cell adhesion molecule

  • Overview

    L1, also known as L1CAM, is a transmembrane protein; it is a neuronal cell adhesion molecule, member of the L1 protein family, of 200-220 kDa, and involved in axon guidance and cell migration with a strong implication in treatment-resistant cancers. L1CAM has also been designated CD171 ( cluster of differentiation 171 ). The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin superfamily of proteins. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats ( type III ), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration, and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH ( corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus ). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
  • Synonyms

    antigen identified by monoclonal antibody R1; CAML1; CD 171; CD171; CD171 antigen; HGNC:7086; HSAS; HSAS1; Hyd; L1; L1 cell adhesion molecule; L1-NCAM; L1cam; L1CAM_HUMAN; MASA; MIC 5; MIC5; N CAM L1; N CAML1; N-CAM-L1; NCAM-L1; NCAML1; Nerve-growth factor-inducible large external glycoprotein; Neural cell adhesion molecule L1; NEURAL CELL ADHESION MOLECULE L1 PRECURSOR; NILE; OTTHUMP00000025992; S10; SPG 1; SPG1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Macaca fascicularis
  • Mouse
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human Cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse myeloma cell line
  • Yeast
  • C
  • His
  • Fc
  • Fc Chimera
  • Fc|His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|Fc
  • His|GST
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human L1CAM-526H Active Recombinant Human L1CAM protein, His/Fc-tagged Mammalian cells His/Fc
Human L1CAM-485H Active Recombinant Human L1CAM, Fc Chimera Mammalian cells Fc Chimera
Human L1CAM-485HAF555 Active Recombinant Human L1CAM Protein, Fc-tagged, Alexa Fluor 555 conjugated Mammalian cells Fc
Human L1CAM-526HAF488 Active Recombinant Human L1CAM Protein, His/Fc-tagged, Alexa Fluor 488 conjugated Mammalian cells His
Human L1CAM-485HAF488 Active Recombinant Human L1CAM Protein, Fc-tagged, Alexa Fluor 488 conjugated Mammalian cells Fc
Human L1CAM-526HAF555 Active Recombinant Human L1CAM Protein, His/Fc-tagged, Alexa Fluor 555 conjugated Mammalian cells His
Human L1CAM-485HF Active Recombinant Human L1CAM Protein, Fc-tagged, FITC conjugated Mammalian cells Fc
Human L1CAM-526HF Active Recombinant Human L1CAM Protein, His/Fc-tagged, FITC conjugated Mammalian cells His
Human L1CAM-485HAF647 Active Recombinant Human L1CAM Protein, Fc-tagged, Alexa Fluor 647 conjugated Mammalian cells Fc
Human L1CAM-526HAF647 Active Recombinant Human L1CAM Protein, His/Fc-tagged, Alexa Fluor 647 conjugated Mammalian cells His
Human L1CAM-26864TH Recombinant Human L1CAM, His-tagged E.coli His
Human L1CAM-628H Recombinant Human L1CAM, Fc-His tagged Human Cell Fc/His
Human L1CAM-1669H Recombinant Human L1 Cell Adhesion Molecule Mammalian cells N/A
Human L1CAM-2416HCL Recombinant Human L1CAM cell lysate Human Cell N/A
Human L1CAM-4399H Recombinant Human L1CAM Protein (Met1-Glu1120), C-His tagged Mammalian cells C-His Met1-Glu1120
Human L1CAM-628HAF555 Recombinant Human L1CAM Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 1348
Human L1CAM-2166H Recombinant Human L1CAM protein, His-tagged HEK293 His Met1-Glu1120
Human L1CAM-5460H Recombinant Human L1CAM protein, His-tagged Yeast His 1003-1114aa
Human L1CAM-3758H Recombinant Human L1CAM protein, GST-tagged E.coli GST 460-660 aa
Human L1CAM-485HA Recombinant Human L1CAM protein, Fc-tagged, APC labeled Mammalian cells Fc
Human L1CAM-553HFL Recombinant Full Length Human L1CAM Protein, C-Flag-tagged Mammalian cells Flag
Human L1CAM-115H Recombinant Human L1CAM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human L1CAM-090H Recombinant Human L1CAM Protein, C-His-tagged E.coli C-His
Human L1CAM-526HA Recombinant Human L1CAM protein, His/Fc-tagged, APC labeled Mammalian cells His/Fc
Human L1CAM-628HAF488 Recombinant Human L1CAM Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 1348
Human L1CAM-628HA Recombinant Human L1CAM protein, Fc-His-tagged, APC labeled HEK293 Fc/His
Human L1CAM-115H-B Recombinant Human L1CAM Protein Pre-coupled Magnetic Beads HEK293
Human L1CAM-628HAF647 Recombinant Human L1CAM Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 1348
Human L1CAM-485HP Recombinant Human L1CAM protein, Fc-tagged, R-PE labeled Mammalian cells Fc
Human L1CAM-151H Recombinant Human L1CAM Protein, His-tagged Human Cells His
Human L1CAM-526HP Recombinant Human L1CAM protein, His/Fc-tagged, R-PE labeled Mammalian cells His/Fc
Human L1CAM-628HF Recombinant Human L1CAM Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 1348
Human L1CAM-628HP Recombinant Human L1CAM protein, Fc-His-tagged, R-PE labeled HEK293 Fc/His
Human L1CAM-0830H Recombinant Human L1CAM Protein (Thr218-Gln423), His tagged E.coli His Thr218-Gln423
Human L1CAM-1276H Recombinant Human L1CAM Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human L1CAM-0831H Recombinant Human L1CAM Protein (Ile20-Glu152), N-His tagged E.coli N-His Ile20-Glu152
Human L1CAM-02H Active Recombinant Human L1CAM protein, His-tagged Insect Cell His 20-1115
Human L1CAM-3153H Recombinant Human L1CAM protein, His-tagged E.coli His 1003-1114aa
Mouse L1cam-5671M Recombinant Mouse L1cam protein, His & GST-tagged E.coli His/GST Ser882~Ala1132 (Accession # P11627)
Mouse L1cam-01M Active Recombinant Mouse L1cam Protein, Fc-tagged Mouse myeloma cell line Fc
Mouse L1cam-1725M Recombinant Mouse L1cam Protein, His-tagged E.coli N-His Ser882-Ala1132
Rat L1CAM-3339R Recombinant Rat L1CAM Protein Mammalian Cell His
Rat L1CAM-2995R Recombinant Rat L1CAM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat L1CAM-2995R-B Recombinant Rat L1CAM Protein Pre-coupled Magnetic Beads HEK293
Rhesus monkey L1CAM-1597R Recombinant Rhesus Monkey L1CAM Protein HEK293 N/A
Macaca fascicularis L1CAM-1597M Recombinant Monkey L1CAM Protein HEK293
Rhesus Macaque L1CAM-2454R Recombinant Rhesus monkey L1CAM Protein, His-tagged Mammalian Cell His
Rhesus Macaque L1CAM-2275R-B Recombinant Rhesus Macaque L1CAM Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque L1CAM-2275R Recombinant Rhesus Macaque L1CAM Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken L1CAM-6710C Recombinant Chicken L1CAM Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

L1CAM involved in several pathways and played different roles in them. We selected most pathways L1CAM participated on our site, such as Axon guidance, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with L1CAM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceJAK3;NADL1.1;GNAI2;ARPC5;NCAN;AGRN;FRS2B;KRAS;EPHB3A
Cell adhesion molecules (CAMs)NCAM1A;Siglec1;CLDNJ;CD274;NLGN2;NRXN3A;PRPSAP2;CLDN15LA;ITGB7

L1CAM has several biochemical functions, for example, identical protein binding, integrin binding, protein self-association. Some of the functions are cooperated with other proteins, some of the functions could acted by L1CAM itself. We selected most functions L1CAM had, and list some proteins which have the same functions with L1CAM. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingCLDN15;DCP1A;BAIAP2;PVRL2;WAS;SMAD6;VEGFA;CLDN17;LYZ
integrin bindingFN1;ITGB1BP2;ITGA5;VWF;FERMT3;ICAM1;GFAP;VTN;S1PR2
protein self-associationZSWIM2;RYR2;RSAD2;ACHE;ABCD3;PTH1R;LDB1;DVL2;AGTR1A
sialic acid bindingST8SIA3;Siglece;ADIPOQ;ST8SIA2;SELP;AGRN;SELE;L1CAM;FCN1

L1CAM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with L1CAM here. Most of them are supplied by our site. Hope this information will be useful for your research of L1CAM.

ganglioside_gm1; aerA; PEA15; Caskin1; cona_canen

Research Area

Related articles

Doberstein, K; Harter, PN; et al. Antibody therapy to human L1CAM in a transgenic mouse model blocks local tumor growth but induces EMT. INTERNATIONAL JOURNAL OF CANCER 136:E326-E339(2015).
Tang, DY; Yu, Y; et al. Single chain fragment variable antibodies developed by using as target the 3rd fibronectin type III homologous repeat fragment of human neural cell adhesion molecule L1 promote cell migration and nemitogenesis. EXPERIMENTAL CELL RESEARCH 330:336-345(2015).
  • Q&As
  • Reviews

Q&As (5)

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Are there any L1CAM-targeted therapies in clinical trials? 08/03/2022

Some clinical trials are exploring L1CAM-targeted therapies in the context of cancer treatment.

Can L1CAM be used as a diagnostic marker for neurological disorders? 11/21/2019

L1CAM mutations can be diagnosed through genetic testing, aiding in the diagnosis of L1 syndrome and related conditions.

Can L1CAM be a therapeutic target in cancer treatment? 07/03/2019

L1CAM has been explored as a potential therapeutic target for inhibiting tumor metastasis in some cancer types.

Are there clinical applications for L1CAM in neurodegenerative diseases? 02/05/2018

L1CAM is not typically associated with neurodegenerative diseases, but its role in neural development may have implications for regenerative medicine.

In what other medical conditions is L1CAM implicated? 10/30/2017

L1CAM has been associated with certain developmental disorders and cognitive deficits in addition to cancer and neurological disorders.

Customer Reviews (3)

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Reviews
04/11/2020

    L1CAM protein is an enzyme involved in the digestion of carbohydrates, specifically starch.

    07/07/2019

      A reliable manufacturer ensures the production and purification of L1CAM protein, maintaining its quality and purity.

      10/08/2017

        Manufacturers should provide detailed information about the production process, quality control measures, and purity assessment methods employed.

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