L1, also known as L1CAM, is a transmembrane protein; it is a neuronal cell adhesion molecule, member of the L1 protein family, of 200-220 kDa, and involved in axon guidance and cell migration with a strong implication in treatment-resistant cancers. L1CAM has also been designated CD171 ( cluster of differentiation 171 ). The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin superfamily of proteins. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats ( type III ), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration, and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH ( corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus ). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
Synonyms
antigen identified by monoclonal antibody R1; CAML1; CD 171; CD171; CD171 antigen; HGNC:7086; HSAS; HSAS1; Hyd; L1; L1 cell adhesion molecule; L1-NCAM; L1cam; L1CAM_HUMAN; MASA; MIC 5; MIC5; N CAM L1; N CAML1; N-CAM-L1; NCAM-L1; NCAML1; Nerve-growth factor-inducible large external glycoprotein; Neural cell adhesion molecule L1; NEURAL CELL ADHESION MOLECULE L1 PRECURSOR; NILE; OTTHUMP00000025992; S10; SPG 1; SPG1;
L1CAM involved in several pathways and played different roles in them. We selected most pathways L1CAM participated on our site, such as Axon guidance, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with L1CAM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
L1CAM has several biochemical functions, for example, identical protein binding, integrin binding, protein self-association. Some of the functions are cooperated with other proteins, some of the functions could acted by L1CAM itself. We selected most functions L1CAM had, and list some proteins which have the same functions with L1CAM. You can find most of the proteins on our site.
L1CAM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with L1CAM here. Most of them are supplied by our site. Hope this information will be useful for your research of L1CAM.
ganglioside_gm1; aerA; PEA15; Caskin1; cona_canen
Doberstein, K; Harter, PN; et al. Antibody therapy to human L1CAM in a transgenic mouse model blocks local tumor growth but induces EMT. INTERNATIONAL JOURNAL OF CANCER 136:E326-E339(2015).
Tang, DY; Yu, Y; et al. Single chain fragment variable antibodies developed by using as target the 3rd fibronectin type III homologous repeat fragment of human neural cell adhesion molecule L1 promote cell migration and nemitogenesis. EXPERIMENTAL CELL RESEARCH 330:336-345(2015).
