Recombinant Human L1CAM Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: L1CAM-1276H
• Product Overview: L1CAM MS Standard C13 and N15-labeled recombinant protein (NP_000416) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 140 kDa
• AA Sequence: MVVALRYVWPLLLCSPCLLIQIPEE YEGHHVMEPPVITEQSPRRLVVFPT DDISLKCEASGKPEVQFRWTRDGVH FKPKEELGVTVYQSPHSGSFTITGN NSNFAQRFQGIYRCFASNKLGTAMS HEIRLMAEGAPKWPKETVKPVEVEE GESVVLPCNPPPSAEPLRIYWMNSK ILHIKQDERVTMGQNGNLYFANVLT SDNHSDYICHAHFPGTRTIIQKEPI DLRVKATNSMIDRKPRLLFPTNSSS HLVALQGQPLVLECIAEGFPTPTIK WLRPSGPMPADRVTYQNHNKTLQLL KVGEEDDGEYRCLAENSLGSARHAY YVTVEAAPYWLHKPQSHLYGPGETA RLDCQVQGRPQPEVTWRINGIPVEE LAKDQKYRIQRGALILSNVQPSDTM VTQCEARNRHGLLLANAYIYVVQLP AKILTADNQTYMAVQGSTAYLLCKA FGAPVPSVQWLDEDGTTVLQDERFF PYANGTLGIRDLQANDTGRYFCLAA NDQNNVTIMANLKVKDATQITQGPR STIEKKGSRVTFTCQASFDPSLQPS ITWRGDGRDLQELGDSDKYFIEDGR LVIHSLDYSDQGNYSCVASTELDVV ESRAQLLVVGSPGPVPRLVLSDLHL LTQSQVRVSWSPAEDHNAPIEKYDI EFEDKEMAPEKWYSLGKVPGNQTST TLKLSPYVHYTFRVTAINKYGPGEP SPVSETVVTPEAAPEKNPVDVKGEG NETTNMVITWKPLRWMDWNAPQVQY RVQWRPQGTRGPWQEQIVSDPFLVV SNTSTFVPYEIKVQAVNSQGKGPEP QVTIGYSGEDYPQAIPELEGIEILN SSAVLVKWRPVDLAQVKGHLRGYNV TYWREGSQRKHSKRHIHKDHVVVPA NTTSVILSGLRPYSSYHLEVQAFNG RGSGPASEFTFSTPEGVPGHPEALH LECQSNTSLLLRWQPPLSHNGVLTG YVLSYHPLDEGGKGQLSFNLRDPEL RTHNLTDLSPHLRYRFQLQATTKEG PGEAIVREGGTMALSGISDFGNISA TAGENYSVVSWVPKEGQCNFRFHIL FKALGEEKGGASLSPQYVSYNQSSY TQWDLQPDTDYEIHLFKERMFRHQM AVKTNGTGRVRLPPAGFATEGWFIG FVSAIILLLLVLLILCFIKRSKGGK YSVKDKEDTQVDSEARPMKDETFGE YRSLESDNEEKAFGSSQPSLNGDIK PLGSDDSLADYGGSVDVQFNEDGSF IGQYSGKKEKEAAGGNDSSGATSPI NPAVALETRTRPLEQKLISEEDLAA NDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: L1CAM L1 cell adhesion molecule [ Homo sapiens (human) ]
• Official Symbol: L1CAM
• Synonyms: L1CAM; L1 cell adhesion molecule; antigen identified by monoclonal R1, HSAS, HSAS1, MASA, MIC5, S10, SPG1; neural cell adhesion molecule L1; CD171; antigen identified by monoclonal R1; S10; HSAS; MASA; MIC5; SPG1; CAML1; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1
• Gene ID: 3897
• mRNA Refseq: NM_000425
• Protein Refseq: NP_000416
• MIM: 308840
• UniProt ID: P32004

Reviews

04/11/2020

L1CAM protein is an enzyme involved in the digestion of carbohydrates, specifically starch.

07/07/2019

A reliable manufacturer ensures the production and purification of L1CAM protein, maintaining its quality and purity.

10/08/2017

Manufacturers should provide detailed information about the production process, quality control measures, and purity assessment methods employed.

Q&As

Are there any L1CAM-targeted therapies in clinical trials?

Some clinical trials are exploring L1CAM-targeted therapies in the context of cancer treatment.

Can L1CAM be used as a diagnostic marker for neurological disorders?

L1CAM mutations can be diagnosed through genetic testing, aiding in the diagnosis of L1 syndrome and related conditions.

Can L1CAM be a therapeutic target in cancer treatment?

L1CAM has been explored as a potential therapeutic target for inhibiting tumor metastasis in some cancer types.

Are there clinical applications for L1CAM in neurodegenerative diseases?

L1CAM is not typically associated with neurodegenerative diseases, but its role in neural development may have implications for regenerative medicine.

In what other medical conditions is L1CAM implicated?

L1CAM has been associated with certain developmental disorders and cognitive deficits in addition to cancer and neurological disorders.