| Description : |
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
140 kDa |
| AA Sequence : |
MVVALRYVWPLLLCSPCLLIQIPEE YEGHHVMEPPVITEQSPRRLVVFPT DDISLKCEASGKPEVQFRWTRDGVH FKPKEELGVTVYQSPHSGSFTITGN NSNFAQRFQGIYRCFASNKLGTAMS HEIRLMAEGAPKWPKETVKPVEVEE GESVVLPCNPPPSAEPLRIYWMNSK ILHIKQDERVTMGQNGNLYFANVLT SDNHSDYICHAHFPGTRTIIQKEPI DLRVKATNSMIDRKPRLLFPTNSSS HLVALQGQPLVLECIAEGFPTPTIK WLRPSGPMPADRVTYQNHNKTLQLL KVGEEDDGEYRCLAENSLGSARHAY YVTVEAAPYWLHKPQSHLYGPGETA RLDCQVQGRPQPEVTWRINGIPVEE LAKDQKYRIQRGALILSNVQPSDTM VTQCEARNRHGLLLANAYIYVVQLP AKILTADNQTYMAVQGSTAYLLCKA FGAPVPSVQWLDEDGTTVLQDERFF PYANGTLGIRDLQANDTGRYFCLAA NDQNNVTIMANLKVKDATQITQGPR STIEKKGSRVTFTCQASFDPSLQPS ITWRGDGRDLQELGDSDKYFIEDGR LVIHSLDYSDQGNYSCVASTELDVV ESRAQLLVVGSPGPVPRLVLSDLHL LTQSQVRVSWSPAEDHNAPIEKYDI EFEDKEMAPEKWYSLGKVPGNQTST TLKLSPYVHYTFRVTAINKYGPGEP SPVSETVVTPEAAPEKNPVDVKGEG NETTNMVITWKPLRWMDWNAPQVQY RVQWRPQGTRGPWQEQIVSDPFLVV SNTSTFVPYEIKVQAVNSQGKGPEP QVTIGYSGEDYPQAIPELEGIEILN SSAVLVKWRPVDLAQVKGHLRGYNV TYWREGSQRKHSKRHIHKDHVVVPA NTTSVILSGLRPYSSYHLEVQAFNG RGSGPASEFTFSTPEGVPGHPEALH LECQSNTSLLLRWQPPLSHNGVLTG YVLSYHPLDEGGKGQLSFNLRDPEL RTHNLTDLSPHLRYRFQLQATTKEG PGEAIVREGGTMALSGISDFGNISA TAGENYSVVSWVPKEGQCNFRFHIL FKALGEEKGGASLSPQYVSYNQSSY TQWDLQPDTDYEIHLFKERMFRHQM AVKTNGTGRVRLPPAGFATEGWFIG FVSAIILLLLVLLILCFIKRSKGGK YSVKDKEDTQVDSEARPMKDETFGE YRSLESDNEEKAFGSSQPSLNGDIK PLGSDDSLADYGGSVDVQFNEDGSF IGQYSGKKEKEAAGGNDSSGATSPI NPAVALETRTRPLEQKLISEEDLAA NDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
