Active Recombinant Human L1CAM protein, His-tagged

Cat.No. : L1CAM-02H
Product Overview : Recombinant human L1CAM, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
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Description : The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.
Source : Insect cell
Species : Human
Tag : His
Form : Liquid
Bio-activity : Measured by the ability of the immobilized protein to support the adhesion of Neuro-2a mouse neuroblastoma cells. When cells are added to human L1CAM coated plates 1 μg/mL. This effect is more to 30 %.
Molecular Mass : 123.6 kDa (1104aa)
Protein length : 20-1115
AA Sequence : IQIPEELMEPPVITEQSPRRLVVFP TDDISLKCEASGKPEVQFRWTRDGV HFKPKEELGVTVYQSPHSGSFTITG NNSNFAQRFQGIYRCFASNKLGTAM SHEIRLMAEGAPKWPKETVKPVEVE EGESVVLPCNPPPSAEPLRIYWMNS KILHIKQDERVTMGQNGNLYFANVL TSDNHSDYICHAHFPGTRTIIQKEP IDLRVKATNSMIDRKPRLLFPTNSS SHLVALQGQPLVLECIAEGFPTPTI KWLRPSGPMPADRVTYQNHNKTLQL LKVGEEDDGEYRCLAENSLGSARHA YYVTVEAAPYWLHKPQSHLYGPGET ARLDCQVQGRPQPEVTWRINGIPVE ELAKDQKYRIQRGALILSNVQPSDT MVTQCEARNRHGLLLANAYIYVVQL PAKILTADNQTYMAVQGSTAYLLCK AFGAPVPSVQWLDEDGTTVLQDERF FPYANGTLGIRDLQANDTGRYFCLA ANDQNNVTIMANLKVKDATQITQGP RSTIEKKGSRVTFTCQASFDPSLQP SITWRGDGRDLQELGDSDKYFIEDG RLVIHSLDYSDQGNYSCVASTELDV VESRAQLLVVGSPGPVPRLVLSDLH LLTQSQVRVSWSPAEDHNAPIEKYD IEFEDKEMAPEKWYSLGKVPGNQTS TTLKLSPYVHYTFRVTAINKYGPGE PSPVSETVVTPEAAPEKNPVDVKGE GNETTNMVITWKPLRWMDWNAPQVQ YRVQWRPQGTRGPWQEQIVSDPFLV VSNTSTFVPYEIKVQAVNSQGKGPE PQVTIGYSGEDYPQAIPELEGIEIL NSSAVLVKWRPVDLAQVKGHLRGYN VTYWREGSQRKHSKRHIHKDHVVVP ANTTSVILSGLRPYSSYHLEVQAFN GRGSGPASEFTFSTPEGVPGHPEAL HLECQSNTSLLLRWQPPLSHNGVLT GYVLSYHPLDEGGKGQLSFNLRDPE LRTHNLTDLSPHLRYRFQLQATTKE GPGEAIVREGGTMALSGISDFGNIS ATAGENYSVVSWVPKEGQCNFRFHI LFKALGEEKGGASLSPQYVSYNQSS YTQWDLQPDTDYEIHLFKERMFRHQ MAVKTNGTGRVRLPPAGFATE
Endotoxin : < 1 EU/μg of protein (determined by LAL method)
Purity : > 90 % by SDS-PAGE
Applications : SDS-PAGE, Bioactivity
Storage : Can be stored at +2 to +8 centigrade for 1 week. For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
Concentration : 0.25 mg/mL
Storage Buffer : PBS (pH 7.4) containing 10% glycerol
SDS-PAGE: 3 μg by SDS-PAGE under reducing condition and visualized by coomassie blue stain
Gene Name : L1CAM L1 cell adhesion molecule [ Homo sapiens (human) ]
Official Symbol : L1CAM
Synonyms : L1CAM; L1 cell adhesion molecule; S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1; neural cell adhesion molecule L1; antigen identified by monoclonal antibody R1
Gene ID : 3897
mRNA Refseq : NM_001143963
Protein Refseq : NP_001137435
MIM : 308840
UniProt ID : P32004

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any L1CAM-targeted therapies in clinical trials? 08/03/2022

Some clinical trials are exploring L1CAM-targeted therapies in the context of cancer treatment.

Can L1CAM be used as a diagnostic marker for neurological disorders? 11/21/2019

L1CAM mutations can be diagnosed through genetic testing, aiding in the diagnosis of L1 syndrome and related conditions.

Can L1CAM be a therapeutic target in cancer treatment? 07/03/2019

L1CAM has been explored as a potential therapeutic target for inhibiting tumor metastasis in some cancer types.

Are there clinical applications for L1CAM in neurodegenerative diseases? 02/05/2018

L1CAM is not typically associated with neurodegenerative diseases, but its role in neural development may have implications for regenerative medicine.

In what other medical conditions is L1CAM implicated? 10/30/2017

L1CAM has been associated with certain developmental disorders and cognitive deficits in addition to cancer and neurological disorders.

Customer Reviews (3)

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Reviews
04/11/2020

    L1CAM protein is an enzyme involved in the digestion of carbohydrates, specifically starch.

    07/07/2019

      A reliable manufacturer ensures the production and purification of L1CAM protein, maintaining its quality and purity.

      10/08/2017

        Manufacturers should provide detailed information about the production process, quality control measures, and purity assessment methods employed.

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