Recombinant Human L1CAM, His-tagged

• Cat.No.: L1CAM-26864TH
• Product Overview: Recombinant fragment, corresponding to amino acids 605-1065 of Human L1CAM with an N-terminal His tag; MWt 53 kDa.

Specification

• Description: The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
• Conjugation: HIS
• Source: E. coli
• Form: Lyophilised:Reconstitute with 58 μl aqua dest
• Storage buffer: Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: (Amino acid sequence (Sequence determined by 5 Sequencing))QLLVVGSPGPVPRLVLSDLHLLTQS Q VRVSWSPAEDHNAPIEKYDIEFEDK EMAPEKWYSLGKV PGNQTSTTLKLSPYVHYTFRVTAIN KYGPGEPSPVSETVVTPEAAPEKNP VDVKGEGNETTNMVITWKPLRWMDW NAP QVQYRVQWRPQGTRGPWQEQIVSDP FLVVSNTSTFVPY EIKVQAVNSQGKGPEPQVTIGYSGE DYPQAIPELEGIE ILNSSAVLVKWRPVDLAQVKGHLRG YNVTYWREGSQRK HSKRHIHKDHVVVPANTTSVILSGL RPYSSYHLEVQAFNG RGSGPASEFTFSTPEGVPGHPEALH LECQSNTSLLLRW QPPLSHNGVLTGYVLSYHPLDEGGK GQLSFNLRDPELR THNLTDLSPHLRYRFQLQATTKEGP GEAIVREGGTMAL SGISDFGNISATAGENYSVVSWVPK EGQCNFRFHILFKAL GEEKGGASLSP
• Sequence Similarities: Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.Contains 5 fibronectin type-III domains.Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

Gene Information

• Gene Name: L1CAM L1 cell adhesion molecule [ Homo sapiens ]
• Official Symbol: L1CAM
• Synonyms: L1CAM; L1 cell adhesion molecule; antigen identified by monoclonal R1 , HSAS, HSAS1, MASA, MIC5, S10, SPG1; neural cell adhesion molecule L1; CD171
• Gene ID: 3897
• mRNA Refseq: NM_000425
• Protein Refseq: NP_000416
• MIM: 308840
• Uniprot ID: P32004
• Chromosome Location: Xq28
• Pathway: Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Basigin interactions, organism-specific biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem
• Function: PDZ domain binding; identical protein binding; integrin binding; protein self-association; sialic acid binding

Reviews

04/11/2020

L1CAM protein is an enzyme involved in the digestion of carbohydrates, specifically starch.

07/07/2019

A reliable manufacturer ensures the production and purification of L1CAM protein, maintaining its quality and purity.

10/08/2017

Manufacturers should provide detailed information about the production process, quality control measures, and purity assessment methods employed.

Q&As

Are there any L1CAM-targeted therapies in clinical trials?

Some clinical trials are exploring L1CAM-targeted therapies in the context of cancer treatment.

Can L1CAM be used as a diagnostic marker for neurological disorders?

L1CAM mutations can be diagnosed through genetic testing, aiding in the diagnosis of L1 syndrome and related conditions.

Can L1CAM be a therapeutic target in cancer treatment?

L1CAM has been explored as a potential therapeutic target for inhibiting tumor metastasis in some cancer types.

Are there clinical applications for L1CAM in neurodegenerative diseases?

L1CAM is not typically associated with neurodegenerative diseases, but its role in neural development may have implications for regenerative medicine.

In what other medical conditions is L1CAM implicated?

L1CAM has been associated with certain developmental disorders and cognitive deficits in addition to cancer and neurological disorders.