Species : |
Human |
Source : |
E.coli |
Tag : |
His |
Protein Length : |
605-1065 a.a. |
Description : |
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant. |
Conjugation : |
HIS |
Form : |
Lyophilised:Reconstitute with 58 μl aqua dest |
Storage buffer : |
Preservative: NoneConstituents: 0.5% Trehalose, 6M Urea, 100mM Sodium phosphate, 10mM Sodium chloride, pH 4.5 |
Storage : |
Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : |
(Amino acid sequence (Sequence determined by 5 Sequencing))QLLVVGSPGPVPRLVLSDLHLLTQSQ VRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKV PGNQTSTTLKLSPYVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRWMDWNAP QVQYRVQWRPQGTRGPWQEQIVSDPFLVVSNTSTFVPY EIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIE ILNSSAVLVKWRPVDLAQVKGHLRGYNVTYWREGSQRK HSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNG RGSGPASEFTFSTPEGVPGHPEALHLECQSNTSLLLRW QPPLSHNGVLTGYVLSYHPLDEGGKGQLSFNLRDPELR THNLTDLSPHLRYRFQLQATTKEGPGEAIVREGGTMAL SGISDFGNISATAGENYSVVSWVPKEGQCNFRFHILFKAL GEEKGGASLSP |
Sequence Similarities : |
Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.Contains 5 fibronectin type-III domains.Contains 6 Ig-like C2-type (immunoglobulin-like) domains. |