Active Recombinant Human L1CAM Protein, His/Fc-tagged, Alexa Fluor 555 conjugated

Cat.No. : L1CAM-526HAF555
Product Overview : Alexa Fluor 555 conjugated recombinant human L1CAM (Accession # EAW63869) Ile25-Gln1096, fused with a C-terminal 10-His tag, was produced in Mouse myeloma cell line, NS0-derived.
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Source : Mammalian cells
Species : Human
Tag : His
Form : Lyophilized
Bio-activity : Measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons.Able to significantly enhance neurite outgrowth when immobilized as a 3 μL droplet containing 100 ng on a nitrocellulose-coated microplate.
Molecular Mass : Recombinant Human L1CAM, His-tagged has a calculated MW of 121.3 kDa. In SDS-PAGE migrates as 160-180 kDa, reducing conditions.
N-terminal Sequence Analysis : Ile 25
Purity : > 95 % by SDS-PAGE under reducing conditions and visualized by silver stain.
Characteristic : Disulfide-linked homodimer
Labeled with Alexa Fluor 555 via amines
With an excitation and emission maximum of 555/565 nm, Alexa Fluor 555 can be efficiently excited using a 543 nm He-Ne laser line and detected under standard TRITC/Cy3 filters.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4 centigrade); After reconstitution under sterile conditions for 3 months (-70 centigrade).
Storage Buffer : Lyophilized from a 0.2 μm filtered solution in PBS.
Gene Name : L1CAM L1 cell adhesion molecule [ Homo sapiens ]
Official Symbol : L1CAM
Synonyms : L1CAM; L1 cell adhesion molecule; antigen identified by monoclonal R1 , HSAS, HSAS1, MASA, MIC5, S10, SPG1; neural cell adhesion molecule L1; CD171; antigen identified by monoclonal R1; S10; HSAS; MASA; MIC5; SPG1; CAML1; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1;
Gene ID : 3897
mRNA Refseq : NM_000425
Protein Refseq : NP_000416
MIM : 308840
UniProt ID : P32004

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any L1CAM-targeted therapies in clinical trials? 08/03/2022

Some clinical trials are exploring L1CAM-targeted therapies in the context of cancer treatment.

Can L1CAM be used as a diagnostic marker for neurological disorders? 11/21/2019

L1CAM mutations can be diagnosed through genetic testing, aiding in the diagnosis of L1 syndrome and related conditions.

Can L1CAM be a therapeutic target in cancer treatment? 07/03/2019

L1CAM has been explored as a potential therapeutic target for inhibiting tumor metastasis in some cancer types.

Are there clinical applications for L1CAM in neurodegenerative diseases? 02/05/2018

L1CAM is not typically associated with neurodegenerative diseases, but its role in neural development may have implications for regenerative medicine.

In what other medical conditions is L1CAM implicated? 10/30/2017

L1CAM has been associated with certain developmental disorders and cognitive deficits in addition to cancer and neurological disorders.

Customer Reviews (3)

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04/11/2020

    L1CAM protein is an enzyme involved in the digestion of carbohydrates, specifically starch.

    07/07/2019

      A reliable manufacturer ensures the production and purification of L1CAM protein, maintaining its quality and purity.

      10/08/2017

        Manufacturers should provide detailed information about the production process, quality control measures, and purity assessment methods employed.

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