Active Recombinant Mouse L1cam Protein, Fc-tagged

Cat.No. : L1cam-01M
Product Overview : Recombinant mouse L1CAM (Met1-Glu1123) with a Phe176Leu Substitution fused with a Human IgG1 (Pro100-Lys330) at C-terminus was expressed in Mouse myeloma cell line NS0.
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Description : Biased expression in CNS E18 (RPKM 43.2), whole brain E14.5 (RPKM 35.1) and 12 other tissues.
Source : Mouse myeloma cell line
Species : Mouse
Tag : Fc
Form : Disulfide-linked homodimer
Bio-activity : Measured by the ability of the immobilized protein to support the adhesion of Neuro-2A mouse neuroblastoma cells. Recombinant Mouse L1CAM Fc Chimera immobilized at 2.5 μg/mL with 100 μL/well will induce >40% cell adhesion.
Optimal dilutions should be determined by each laboratory for each application.
Molecular Mass : 150.5 kDa
N-terminal Sequence Analysis : Ile20
Endotoxin : < 0.1 EU/μg of the protein by the LAL method.
Purity : > 95% by SDS-PAGE under reducing conditions and visualized by silver stain.
Applications : Bioactivity
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution in MES and NaCl.
Reconstitution : Reconstitute at 200 μg/mL in PBS.
Shipping : The product is shipped at ambient temperature.
Gene Name : L1cam L1 cell adhesion molecule [ Mus musculus (house mouse) ]
Official Symbol : L1cam
Synonyms : L1cam; L1 cell adhesion molecule; L; L1; L1-N; NCAM; CD171; NCAM-L1; N-CAM-L1; neural cell adhesion molecule L1
Gene ID : 16728
mRNA Refseq : NM_008478
Protein Refseq : NP_032504
UniProt ID : P11627

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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Q&As (5)

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Are there any L1CAM-targeted therapies in clinical trials? 08/03/2022

Some clinical trials are exploring L1CAM-targeted therapies in the context of cancer treatment.

Can L1CAM be used as a diagnostic marker for neurological disorders? 11/21/2019

L1CAM mutations can be diagnosed through genetic testing, aiding in the diagnosis of L1 syndrome and related conditions.

Can L1CAM be a therapeutic target in cancer treatment? 07/03/2019

L1CAM has been explored as a potential therapeutic target for inhibiting tumor metastasis in some cancer types.

Are there clinical applications for L1CAM in neurodegenerative diseases? 02/05/2018

L1CAM is not typically associated with neurodegenerative diseases, but its role in neural development may have implications for regenerative medicine.

In what other medical conditions is L1CAM implicated? 10/30/2017

L1CAM has been associated with certain developmental disorders and cognitive deficits in addition to cancer and neurological disorders.

Customer Reviews (3)

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    L1CAM protein is an enzyme involved in the digestion of carbohydrates, specifically starch.


      A reliable manufacturer ensures the production and purification of L1CAM protein, maintaining its quality and purity.


        Manufacturers should provide detailed information about the production process, quality control measures, and purity assessment methods employed.

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