Recombinant Human L1CAM protein, GST-tagged

• Cat.No.: L1CAM-3758H
• Product Overview: Recombinant Human L1CAM protein(460-660 aa), fused to GST tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: GST
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 100mM GSH.
• Protein length: 460-660 aa
• AA Sequence: WLDEDGTTVLQDERFFPYANGTLGI RDLQANDTGRYFCLAANDQNNVTIM ANLKVKDATQITQGPRSTIEKKGSR VTFTCQASFDPSLQPSITWRGDGRD LQELGDSDKYFIEDGRLVIHSLDYS DQGNYSCVASTELDVVESRAQLLVV GSPGPVPRLVLSDLHLLTQSQVRVS WSPAEDHNAPIEKYDIEFEDKEMAP E
• Purity: 90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks).
  Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
• Reconstitution: Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
  Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.

Gene Information

• Gene Name: L1CAM L1 cell adhesion molecule [ Homo sapiens ]
• Official Symbol: L1CAM
• Synonyms: L1CAM; L1 cell adhesion molecule; antigen identified by monoclonal R1 , HSAS, HSAS1, MASA, MIC5, S10, SPG1; neural cell adhesion molecule L1; CD171; antigen identified by monoclonal R1; S10; HSAS; MASA; MIC5; SPG1; CAML1; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1
• Gene ID: 3897
• mRNA Refseq: NM_000425
• Protein Refseq: NP_000416
• MIM: 308840
• UniProt ID: P32004

Reviews

04/11/2020

L1CAM protein is an enzyme involved in the digestion of carbohydrates, specifically starch.

07/07/2019

A reliable manufacturer ensures the production and purification of L1CAM protein, maintaining its quality and purity.

10/08/2017

Manufacturers should provide detailed information about the production process, quality control measures, and purity assessment methods employed.

Q&As

Are there any L1CAM-targeted therapies in clinical trials?

Some clinical trials are exploring L1CAM-targeted therapies in the context of cancer treatment.

Can L1CAM be used as a diagnostic marker for neurological disorders?

L1CAM mutations can be diagnosed through genetic testing, aiding in the diagnosis of L1 syndrome and related conditions.

Can L1CAM be a therapeutic target in cancer treatment?

L1CAM has been explored as a potential therapeutic target for inhibiting tumor metastasis in some cancer types.

Are there clinical applications for L1CAM in neurodegenerative diseases?

L1CAM is not typically associated with neurodegenerative diseases, but its role in neural development may have implications for regenerative medicine.

In what other medical conditions is L1CAM implicated?

L1CAM has been associated with certain developmental disorders and cognitive deficits in addition to cancer and neurological disorders.