Recombinant Human L1CAM Protein, C-His-tagged

Cat.No. : L1CAM-090H
Product Overview : Recombinant Human L1CAM Protein with C-His tag was expressed in E. coli.
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Description : Neural cell adhesion molecule L1 (NCAM-L1/L1CAM) is a single pass transmembrane glycoprotein member of the immunoglobulin superfamily, containing six amino-terminal extracellular Ig-like domains followed by five fibronectin type-III domains. NCAM-L1 is mainly expressed in the brain, and plays an important role in the developing nervous system, with involvement in neurite fasciculation and outgrowth, myelination, neuronal migration, and neuronal cell adhesion. Mutations in the NCAM-L1 gene cause varying degrees of neurological disease including X-linked hydrocephalus, MASA syndrome, spastic paraplegia type 1, and X-linked corpus callosum agenesis, together known as L1 syndrome. Apart from the nervous system, NCAM-L1 is overexpressed in many cancers and supports a poor prognosis by facilitating aggressive tumor growth, metastasis and chemoresistance.
Source : E. coli
Species : Human
Tag : C-His
Molecular Mass : ~36 kDa
AA Sequence : QGKGPEPQVTIGYSGEDYPQAIPEL EGIEILNSSAVLVKWRPVDLAQVKG HLRGYNVTYWREGSQRKHSKRHIHK DHVVVPANTTSVILSGLRPYSSYHL EVQAFNGRGSGPASEFTFSTPEGVP GHPEALHLECQSNTSLLLRWQPPLS HNGVLTGYVLSYHPLDEGGKGQLSF NLRDPELRTHNLTDLSPHLRYRFQL QATTKEGPGEAIVREGGTMALSGIS DFGNISATAGENYSVVSWVPKEGQC NFRFHILFKALGEEKGGASLSPQYV SYNQSSYTQWDLQPDTDYEIHLFKE RMFRHQMAVKTNGTGRVRLPPAGFA TE
Purity : Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
Notes : For research use only, not for use in diagnostic procedure.
Storage : Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
Concentration : ≥0.5 mg/mL
Storage Buffer : PBS, 4M Urea, pH7.4
SDS-PAGE:
Gene Name : L1CAM L1 cell adhesion molecule [ Homo sapiens (human) ]
Official Symbol : L1CAM
Synonyms : L1CAM; L1 cell adhesion molecule; antigen identified by monoclonal R1 , HSAS, HSAS1, MASA, MIC5, S10, SPG1; neural cell adhesion molecule L1; CD171; antigen identified by monoclonal R1; S10; HSAS; MASA; MIC5; SPG1; CAML1; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1;
Gene ID : 3897
mRNA Refseq : NM_000425
Protein Refseq : NP_000416
MIM : 308840
UniProt ID : P32004

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any L1CAM-targeted therapies in clinical trials? 08/03/2022

Some clinical trials are exploring L1CAM-targeted therapies in the context of cancer treatment.

Can L1CAM be used as a diagnostic marker for neurological disorders? 11/21/2019

L1CAM mutations can be diagnosed through genetic testing, aiding in the diagnosis of L1 syndrome and related conditions.

Can L1CAM be a therapeutic target in cancer treatment? 07/03/2019

L1CAM has been explored as a potential therapeutic target for inhibiting tumor metastasis in some cancer types.

Are there clinical applications for L1CAM in neurodegenerative diseases? 02/05/2018

L1CAM is not typically associated with neurodegenerative diseases, but its role in neural development may have implications for regenerative medicine.

In what other medical conditions is L1CAM implicated? 10/30/2017

L1CAM has been associated with certain developmental disorders and cognitive deficits in addition to cancer and neurological disorders.

Customer Reviews (3)

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Reviews
04/11/2020

    L1CAM protein is an enzyme involved in the digestion of carbohydrates, specifically starch.

    07/07/2019

      A reliable manufacturer ensures the production and purification of L1CAM protein, maintaining its quality and purity.

      10/08/2017

        Manufacturers should provide detailed information about the production process, quality control measures, and purity assessment methods employed.

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