Recombinant Human L1CAM Protein, C-His-tagged

• Cat.No.: L1CAM-090H
• Product Overview: Recombinant Human L1CAM Protein with C-His tag was expressed in E. coli.

Specification

• Description: Neural cell adhesion molecule L1 (NCAM-L1/L1CAM) is a single pass transmembrane glycoprotein member of the immunoglobulin superfamily, containing six amino-terminal extracellular Ig-like domains followed by five fibronectin type-III domains. NCAM-L1 is mainly expressed in the brain, and plays an important role in the developing nervous system, with involvement in neurite fasciculation and outgrowth, myelination, neuronal migration, and neuronal cell adhesion. Mutations in the NCAM-L1 gene cause varying degrees of neurological disease including X-linked hydrocephalus, MASA syndrome, spastic paraplegia type 1, and X-linked corpus callosum agenesis, together known as L1 syndrome. Apart from the nervous system, NCAM-L1 is overexpressed in many cancers and supports a poor prognosis by facilitating aggressive tumor growth, metastasis and chemoresistance.
• Source: E. coli
• Species: Human
• Tag: C-His
• Molecular Mass: ~36 kDa
• AA Sequence: QGKGPEPQVTIGYSGEDYPQAIPEL EGIEILNSSAVLVKWRPVDLAQVKG HLRGYNVTYWREGSQRKHSKRHIHK DHVVVPANTTSVILSGLRPYSSYHL EVQAFNGRGSGPASEFTFSTPEGVP GHPEALHLECQSNTSLLLRWQPPLS HNGVLTGYVLSYHPLDEGGKGQLSF NLRDPELRTHNLTDLSPHLRYRFQL QATTKEGPGEAIVREGGTMALSGIS DFGNISATAGENYSVVSWVPKEGQC NFRFHILFKALGEEKGGASLSPQYV SYNQSSYTQWDLQPDTDYEIHLFKE RMFRHQMAVKTNGTGRVRLPPAGFA TE
• Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
• Concentration: ≥0.5 mg/mL
• Storage Buffer: PBS, 4M Urea, pH7.4

Gene Information

• Gene Name: L1CAM L1 cell adhesion molecule [ Homo sapiens (human) ]
• Official Symbol: L1CAM
• Synonyms: L1CAM; L1 cell adhesion molecule; antigen identified by monoclonal R1 , HSAS, HSAS1, MASA, MIC5, S10, SPG1; neural cell adhesion molecule L1; CD171; antigen identified by monoclonal R1; S10; HSAS; MASA; MIC5; SPG1; CAML1; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1
• Gene ID: 3897
• mRNA Refseq: NM_000425
• Protein Refseq: NP_000416
• MIM: 308840
• UniProt ID: P32004