Recombinant Mouse Ldlr Protein, MYC/DDK-tagged

• Cat.No.: Ldlr-1308M
• Product Overview: Purified recombinant protein of full-length mouse low density lipoprotein receptor (Ldlr), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.

Specification

• Description: Ubiquitous expression in colon adult (RPKM 56.3), adrenal adult (RPKM 52.3) and 27 other tissues
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 94.9 kDa
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 µg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ldlr low density lipoprotein receptor [ Mus musculus (house mouse) ]
• Official Symbol: Ldlr
• Synonyms: Ldlr; low density lipoprotein receptor; Hlb301; low-density lipoprotein receptor; LDL receptor
• Gene ID: 16835
• mRNA Refseq: NM_010700
• Protein Refseq: NP_034830
• UniProt ID: P35951

Reviews

08/11/2020

The LDLR protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

10/07/2018

Its purity and consistency guarantee reliable and reproducible results, ensuring the reliability of my research outcomes.

03/04/2017

the LDLR protein offers superior quality and reliability, making it a perfect fit for my experimental needs.

Q&As

Are there conditions where upregulation of LDLR might be beneficial?

Yes, conditions where increasing the expression or function of LDLR could potentially aid in reducing circulating LDL cholesterol and minimizing cardiovascular risk.

Are there ongoing research efforts regarding LDLR and its clinical applications?

Yes, research is continually conducted to better understand LDLR-related conditions and to develop more effective treatments, including gene-editing technologies and novel therapies.

What are the clinical implications of LDLR dysfunction?

Dysfunction in LDLR can lead to high levels of LDL cholesterol in the blood, contributing to conditions like familial hypercholesterolemia and an increased risk of heart disease.

How does LDLR impact atherosclerosis?

A dysfunctional LDLR can lead to an accumulation of LDL cholesterol in the arteries, promoting atherosclerosis, the hardening and narrowing of arteries.

What treatment options exist for LDLR-related conditions?

Treatments involve lifestyle changes, cholesterol-lowering medications, and in some cases, gene therapies or specialized medications targeting the LDL receptor.