Recombinant Human LDLR protein, His-tagged, Biotinylated

Cat.No. : LDLR-266H
Product Overview : Biotinylated Recombinant Human LDLR protein(NP_000518.1)(Met1-Arg788), fused with His tag, was expressed in HEK293.
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Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from sterile PBS, pH 7.4Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant human LDLR consists of 777 amino acids and predicts a molecular mass of 86 kDa.
Protein Length : Met1-Arg788
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 85 % as determined by SDS-PAGE
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : LDLR low density lipoprotein receptor [ Homo sapiens ]
Official Symbol : LDLR
Synonyms : LDLR; low density lipoprotein receptor; low-density lipoprotein receptor; familial hypercholesterolemia; LDL receptor; low-density lipoprotein receptor class A domain-containing protein 3; FH; FHC; LDLCQ2;
Gene ID : 3949
mRNA Refseq : NM_000527
Protein Refseq : NP_000518
MIM : 606945
UniProt ID : P01130

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there conditions where upregulation of LDLR might be beneficial? 03/17/2022

Yes, conditions where increasing the expression or function of LDLR could potentially aid in reducing circulating LDL cholesterol and minimizing cardiovascular risk.

Are there ongoing research efforts regarding LDLR and its clinical applications? 09/02/2021

Yes, research is continually conducted to better understand LDLR-related conditions and to develop more effective treatments, including gene-editing technologies and novel therapies.

What are the clinical implications of LDLR dysfunction? 09/01/2020

Dysfunction in LDLR can lead to high levels of LDL cholesterol in the blood, contributing to conditions like familial hypercholesterolemia and an increased risk of heart disease.

How does LDLR impact atherosclerosis? 05/27/2020

A dysfunctional LDLR can lead to an accumulation of LDL cholesterol in the arteries, promoting atherosclerosis, the hardening and narrowing of arteries.

What treatment options exist for LDLR-related conditions? 02/23/2018

Treatments involve lifestyle changes, cholesterol-lowering medications, and in some cases, gene therapies or specialized medications targeting the LDL receptor.

Customer Reviews (3)

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08/11/2020

    The LDLR protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

    10/07/2018

      Its purity and consistency guarantee reliable and reproducible results, ensuring the reliability of my research outcomes.

      03/04/2017

        the LDLR protein offers superior quality and reliability, making it a perfect fit for my experimental needs.

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