MICA
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Official Full Name
MHC class I polypeptide-related sequence A
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Overview
MICA and MICB (Major Histocompatibility Complex class I Chain-related gene A and gene B) bind to the activating immunoreceptor NKG2D. NKG2D is expressed on NK (Natural Killer) cells, NKT cells, ??T cells and CD8+??T cells. Recognition of MICA and MICB by -
Synonyms
MICA; MHC class I polypeptide-related sequence A; PERB11.1; HLA class I antigen; stress inducible class I homolog; MHC class I chain-related protein A; MIC-A; FLJ36918; FLJ60820; MGC21250; MGC111087;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus
- Human
- CHO
- CHO cells
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian cells
- Wheat Germ
- C
- Fc
- His
- Fc Chimera
- Avi
- Flag
- GST
- His (Fc)
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- MICA Related Articles
- MICA Related Research Area
MICA involved in several pathways and played different roles in them. We selected most pathways MICA participated on our site, such as Adaptive Immune System, Allograft Rejection, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with MICA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | CYBB;GRAP2B;CD226;LILRB4;KIF18A;UBA5;LRSAM1;SIGLEC12;CTSD |
| Allograft Rejection | HLA-DPB1;H2-Q10;HLA-B;HLA-DRB1;H2-AA;HLA-DRB5;H2-AB1;HLA-DPA1;HLA-DQA2 |
| Immune System | PLD4;CHST13;CMTM2A;UBE2E3;OSCAR;RNF123;WASF3;CTLA4;DEFB119 |
| Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell | CD300LF;TREML2;CD160;CD300A;SIGLEC6;LILRA3;ICAM4;LILRB2;TREML4 |
| Natural killer cell mediated cytotoxicity | CD48;SHC2;HLA-B;IFNAR1;FCGR3B;Raet1a;SHC3;IFNA10;IFNB1 |
MICA has several biochemical functions, for example, NOT beta-2-microglobulin binding, natural killer cell lectin-like receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MICA itself. We selected most functions MICA had, and list some proteins which have the same functions with MICA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT beta-2-microglobulin binding | |
| natural killer cell lectin-like receptor binding | H60a;MICA;ULBP2;CLEC2G;Raet1a;HLA-E;ULBP1;Raet1c;Mill2 |
| protein binding | SLC6A3;RAMP3;TPI1;NUTF2;FAM9B;PDK3;FSHR;CD72;CD8B1 |
MICA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MICA here. Most of them are supplied by our site. Hope this information will be useful for your research of MICA.
KLRK1; LGALS3; POT1
- Q&As
- Reviews
Q&As (5)
Ask a questionMICA expression can change during viral infections and influence the immune response to the pathogen.
Monoclonal antibodies and immunotherapies can target MICA on cancer cells, making them more susceptible to immune system attack.
Yes, tests like immunohistochemistry and flow cytometry can measure MICA expression on tumor cells and help in cancer diagnosis and treatment planning.
Altered MICA expression has been associated with some autoimmune diseases, such as rheumatoid arthritis, suggesting a potential role in disease development.
Yes, MICA polymorphisms can influence the success of organ transplantation by affecting the compatibility between donor and recipient.
Customer Reviews (3)
Write a reviewwhen utilized in Western Blotting experiments, the MICA protein has consistently produced distinct and well-defined protein bands, facilitating clear and accurate interpretation of results.
I have successfully implemented the MICA protein in protein electron microscopy structure analysis, where its attributes have greatly aided in elucidating complex molecular structures.
Considering its remarkable performance across multiple assays, I wholeheartedly endorse the usage of the MICA protein in various research studies.
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