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Recombinant Human MICA Protein, GST-tagged

Cat.No. : MICA-5319H
Product Overview : Human MICA full-length ORF ( NP_000238.1, 1 a.a. - 383 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 69.3 kDa
AA Sequence : MGLGPVFLLLAGIFPFAPPGAAAEP HSLRYNLTVLSWDGSVQSGFLTEVH LDGQPFLRCDRQKCRAKPQGQWAED VLGNKTWDRETRDLTGNGKDLRMTL AHIKDQKEGLHSLQEIRVCEIHEDN STRSSQHFYYDGELFLSQNLETKEW TMPQSSRAQTLAMNVRNFLKEDAMK TKTHYHAMHADCLQELRRYLKSGVV LRRTVPPMVNVTRSEASEGNITVTC RASGFYPWNITLSWRQDGVSLSHDT QQWGDVLPDGNGTYQTWVATRICQG EEQRFTCYMEHSGNHSTHPVPSGKV LVLQSHWQTFHVSAVAAAAIFVIII FYVRCCKKKTSAAEGPELVSLQVLD QHPVGTSDHRDATQLGFQPLMSDLG STGSTEGA
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : MICA MHC class I polypeptide-related sequence A [ Homo sapiens ]
Official Symbol : MICA
Synonyms : MICA; MHC class I polypeptide-related sequence A; PERB11.1; HLA class I antigen; stress inducible class I homolog; MHC class I chain-related protein A; MIC-A; FLJ36918; FLJ60820; MGC21250; MGC111087;
Gene ID : 100507436
mRNA Refseq : NM_000247
Protein Refseq : NP_000238
MIM : 600169
UniProt ID : Q29983

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does MICA relate to infectious diseases? 05/01/2022

MICA expression can change during viral infections and influence the immune response to the pathogen.

How can MICA protein be targeted in cancer therapy? 09/01/2021

Monoclonal antibodies and immunotherapies can target MICA on cancer cells, making them more susceptible to immune system attack.

Are there diagnostic tests that measure MICA expression in cancer patients? 11/10/2019

Yes, tests like immunohistochemistry and flow cytometry can measure MICA expression on tumor cells and help in cancer diagnosis and treatment planning.

What are the implications of MICA expression in autoimmune diseases? 08/27/2018

Altered MICA expression has been associated with some autoimmune diseases, such as rheumatoid arthritis, suggesting a potential role in disease development.

Can MICA polymorphisms affect the outcome of organ transplantation? 05/09/2016

Yes, MICA polymorphisms can influence the success of organ transplantation by affecting the compatibility between donor and recipient.

Customer Reviews (3)

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Reviews
01/16/2022

    when utilized in Western Blotting experiments, the MICA protein has consistently produced distinct and well-defined protein bands, facilitating clear and accurate interpretation of results.

    01/18/2020

      I have successfully implemented the MICA protein in protein electron microscopy structure analysis, where its attributes have greatly aided in elucidating complex molecular structures.

      03/23/2016

        Considering its remarkable performance across multiple assays, I wholeheartedly endorse the usage of the MICA protein in various research studies.

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