| Description : |
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
42.9 kDa |
| AA Sequence : |
MGLGPVFLLLAGIFPFAPPGAAAEP HSLRYNLTVLSWDGSVQSGFLTEVH LDGQPFLRCDRQKCRAKPQGQWAED VLGNKTWDRETRDLTGNGKDLRMTL AHIKDQKEGLHSLQEIRVCEIHEDN STRSSQHFYYDGELFLSQNLETEEW TMPQSSRAQTLAMNVRNFLKEDAMK TKTHYHAMHADCLQELRRYLKSGVV LRRTVPPMVNVTRSEASEGNITVTC RASGFYPWNITLSWRQDGVSLSHDT QQWGDVLPDGNGTYQTWVATRICQG EEQRFTCYMEHSGNHSTHPVPSGKV LVLQSHWQTFHVSAVAAAAIFVIII FYVRCCKKKTSAAEGPELVSLQVLD QHPVGTSDHRDATQLGFQPLMSDLG STGSTEGTTRTRPLEQKLISEEDLA ANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
