sod1
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  • Official Full Name
  • superoxide dismutase 1, soluble
  • Background
  • The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • SOD1; superoxide dismutase 1, soluble; ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer; superoxide dismutase [Cu-Zn]; SOD, soluble; indophenoloxidase A; Cu/Zn superoxide dismutase; superoxide dismutase, cystolic; epididymis secretory protein Li 44;
Cat.#:SOD1-1037HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOD1 Protein
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Cat.#:SOD1-1158HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SOD1 Protein, MYC/DDK-tagged
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Cat.#:sod1-1373ZTag:His-SUMO/MYC
Source (Host):E. coliSpecies:Zebrafish
Product nameRecombinant Zebrafish sod1 Protein, His-SUMO/MYC-tagged
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Cat.#:SOD1-1635HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Superoxide Dismutase 1, Soluble, GST-tagged
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Cat.#:SOD1-04HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Superoxide Dismutase
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Cat.#:SOD1-05HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOD1 protein
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Cat.#:SOD1-103HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOD1, low endotoxin
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Cat.#:SOD1-104HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOD1
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Cat.#:SOD1-1161HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOD1, His tagged
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Cat.#:SOD1-1432HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOD1
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Cat.#:SOD1-1570HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinent Human SOD1 protein
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Cat.#:SOD1-170HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOD1 Protein, His-tagged
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Cat.#:SOD1-200HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Superoxide Dismutase 1
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Cat.#:SOD1-30341THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOD1
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Cat.#:SOD1-326HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Superoxide Dismutase 1, Soluble, His-tagged
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Cat.#:SOD1-328HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOD1 protein, His/MBP-tagged
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Cat.#:SOD1-642HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOD1, His-tagged
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Cat.#:SOD1-6992HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOD1, GST-tagged
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Cat.#:SOD1-8HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human Superoxide Dismutase
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Cat.#:SOD1-15749MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SOD1 Protein
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Cat.#:Sod1-2023MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Sod1 protein, His-tagged
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Cat.#:Sod1-2026RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sod1 protein, His-tagged
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Cat.#:SOD1-5666RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SOD1 Protein
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Cat.#:SOD1-956CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus SOD1 Protein, His-tagged
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Cat.#:SOD1-4405RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SOD1 Protein, His-tagged
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Cat.#:SOD1-2022CTag:His/T7
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken SOD1 protein, His & T7-tagged
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Cat.#:SOD1-2027RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit SOD1 protein, His-tagged
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Cat.#:SOD1-6621CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SOD1
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Cat.#:SOD1-8884ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SOD1
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Cat.#:SOD1-2020CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle SOD1 protein, His-tagged
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Cat.#:SOD1-2021HTag:His/T7
Source (Host):E. coliSpecies:Horse
Product nameRecombinant Horse SOD1 protein, His & T7-tagged
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Cat.#:SOD1-2024STag:His/T7
Source (Host):E. coliSpecies:Sheep
Product nameRecombinant Sheep SOD1 protein, His & T7-tagged
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Cat.#:SOD1-2025PTag:His/T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig SOD1 protein, His & T7-tagged
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Cat.#:SOD1-101BTag:
Source (Host):Species:Bovine
Product nameNative Bovine SOD
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Cat.#:SOD1-102BTag:
Source (Host):Species:Bovine
Product nameNative Bovine SOD, modified
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Cat.#:SOD1-1576HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SOD1 293 Cell Lysate
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Involved Pathway

SOD1 involved in several pathways and played different roles in them. We selected most pathways SOD1 participated on our site, such as Peroxisome, Amyotrophic lateral sclerosis (ALS), Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Peroxisome
ECH1; PHYH; PEX10; PEX7; SCP2; AGXTB; CRATA; PEX6; PEX5; ACOX3
Amyotrophic lateral sclerosis (ALS)
CCS; SLC1A2; GRIN2D; Casp3; BCL2; BAX; GRIN2C; GPX1; GRIN2B; CASP12
Huntingtons disease
MT-ATP6; COX7B2; DNAI2; DNAL4; CYCS; BDNF; POLR2J; POLR2H; ATP5J; NDUFA8
Prion diseases
MAP2K1; C1QB; LOC100033925; MAPK1; CASP12; ELK1; IL1B; HSPA1A; MAPK3; C1QA

Protein Function

SOD1 has several biochemical functions, for example, Rac GTPase binding, chaperone binding, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOD1 itself. We selected most functions SOD1 had, and list some proteins which have the same functions with SOD1. You can find most of the proteins on our site.
Function
Related Protein
Function Rac GTPase binding
Related Protein CAV1; PAK4; MAP3K11; PKN1; SRGAP2B; PAK2A; HACE1; SRGAP2A; FMNL1; DOCK7
Function chaperone binding
Related Protein BAG3; DNLZ; DNAJC10; DNAJA3A; PIH1D3; HSCB; TIMM10; CDKN1B; UBL4; DNAJA4
Function copper ion binding
Related Protein IL1A; ATP7B; TYRP1B; LOXL3A; COMMD1; METTL17; LOXL5B; TP53; ATP7A; S100A5
Function identical protein binding
Related Protein PPP5C; TPRGL; TOPBP1; NME1; MPZL2B; DPP9; PARK7; CLDN2; DIAPH1; PYDC3
Function protein binding
Related Protein DDR2; CTDP1; MPZL2; THOC1; H2AFX; SKAP2; NMNAT1; TFAM; VEGFA; CYP2S1
Function protein homodimerization activity
Related Protein BCL2A; MAP3K11; RAG1; DAXX; CAMK2D; BCL11A; ASGR1; GSTM2; BMP4; PVRL3B
Function protein phosphatase 2B binding
Related Protein PPP3CB; ATP2B4; BAD; AKAP5; AKAP1; SLC9A1; MYOZ2; SOD1
Function superoxide dismutase activity
Related Protein SOD1; SOD3A; SOD2; PRNPA; CCS; NQO1
Function zinc ion binding
Related Protein TRIM22; SYVN1; PDZRN4; PCGF3; ZDHHC16B; ESR2; MDM4; PHF14; MUL1; SRSF7

Interacting Protein

SOD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOD1.
Chga; Chgb; DYNC2LI1; RAC1; BAG3

SOD1 Related Articles

Malaspina, A; Puentes, F; et al. Disease origin and progression in amyotrophic lateral sclerosis: an immunology perspective. INTERNATIONAL IMMUNOLOGY 27:117-129(2015).
Xu, GL; Ayers, JI; et al. Direct and indirect mechanisms for wild-type SOD1 to enhance the toxicity of mutant SOD1 in bigenic transgenic mice. HUMAN MOLECULAR GENETICS 24:1019-1035(2015).