Recombinant Human SRC protein, His-tagged
Cat.No. : | SRC-29696TH |
Product Overview : | Recombinant Human SRC fused with His tag at N-terminal was expressed in Insect cells. |
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Description : | This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. |
Source : | Insect cells |
Species : | Human |
Tag : | His |
Form : | 25 mM Tris-HCl, pH 8.0, 69 mM NaCl, 1.35 mM KCl, 0.025% Tween-20, 125 mM imidazole, 50% glycerol, and 3 mM DTT |
Bio-activity : | 205 pmol/min/μg |
Molecular Mass : | 60.5 kDa |
Purity : | > 85% |
Applications : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Storage : | >6 months at –80 centigrade. Avoid freeze/thaw cycles |
Concentration : | 1.2 mg/ml |
Gene Name : | SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [ Homo sapiens ] |
Official Symbol : | SRC |
Synonyms : | SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); SRC1, v src avian sarcoma (Schmidt Ruppin A 2) viral oncogene homolog; proto-oncogene tyrosine-protein kinase Src; ASV; c src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; SRC1; c-SRC; p60-Src; |
Gene ID : | 6714 |
mRNA Refseq : | NM_005417 |
Protein Refseq : | NP_005408 |
MIM : | 190090 |
UniProt ID : | P12931 |
Chromosome Location : | 20q12-q13 |
Pathway : | ADP signalling through P2Y purinoceptor 1, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Alpha-synuclein signaling, organism-specific biosystem; |
Function : | ATP binding; SH2 domain binding; SH3/SH2 adaptor activity; ephrin receptor binding; heme binding; integrin binding; ion channel binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; |
Products Types
◆ Recombinant Protein | ||
SRC-2094H | Recombinant Human SRC Protein, His (Fc)-Avi-tagged | +Inquiry |
SRC-004H | Active Recombinant Human SRC Protein, GST-tagged | +Inquiry |
Src-1368M | Recombinant Mus musculus Src Protein (V85-L535) | +Inquiry |
SRC-10H | Active Recombinant Human SRC Protein (Full Length), N-FLAG | +Inquiry |
SRC-4276R | Recombinant Rhesus Macaque SRC Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
SRC-29697TH | Native Human SRC | +Inquiry |
◆ Lysates | ||
SRC-487HCL | Recombinant Human SRC cell lysate | +Inquiry |
SRC-585MCL | Recombinant Mouse SRC cell lysate | +Inquiry |
Related Gene
Not For Human Consumption!
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Write a reviewTop-notch protein purification service, essential for our research.
Reliable mass spectrometry analysis, pivotal for our proteomics work.
Swift and reliable protein sequencing, indispensable for our research success.
Q&As (7)
Ask a questionChanges in SRC expression or kinase activity can lead to drug resistance in cancer treatment.
SRC regulates cell proliferation and survival through its kinase activity, influencing various signaling pathways.
SRC is involved in bone remodeling, regulating osteoclast activity and bone resorption.
SRC plays a crucial role in cancer progression, particularly in enhancing metastatic potential of tumor cells.
SRC influences key cellular signaling pathways like Ras/MAPK and PI3K/Akt, affecting cell growth and survival.
SRC modulates cellular adhesion and migration, playing a role in tissue repair and cancer metastasis.
SRC inhibition is a target in cancer therapy, potentially reducing tumor growth and metastasis.
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