Recombinant Human SRC protein

• Cat.No.: SRC-3526H
• Product Overview: Recombinant Human SRC protein(P12931)(2-536aa) was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: Non
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 59.7 kDa
• Protein length: 2-536aa
• AA Sequence: GSNKSKPKDASQRRRSLEPAENVHG AGGGAFPASQTPSKPASADGHRGPS AAFAPAAAEPKLFGGFNSSDTVTSP QRAGPLAGGVTTFVALYDYESRTET DLSFKKGERLQIVNNTEGDWWLAHS LSTGQTGYIPSNYVAPSDSIQAEEW YFGKITRRESERLLLNAENPRGTFL VRESETTKGAYCLSVSDFDNAKGLN VKHYKIRKLDSGGFYITSRTQFNSL QQLVAYYSKHADGLCHRLTTVCPTS KPQTQGLAKDAWEIPRESLRLEVKL GQGCFGEVWMGTWNGTTRVAIKTLK PGTMSPEAFLQEAQVMKKLRHEKLV QLYAVVSEEPIYIVTEYMSKGSLLD FLKGETGKYLRLPQLVDMAAQIASG MAYVERMNYVHRDLRAANILVGENL VCKVADFGLARLIEDNEYTARQGAK FPIKWTAPEAALYGRFTIKSDVWSF GILLTELTTKGRVPYPGMVNREVLD QVERGYRMPCPPECPESLHDLMCQC WRKEPEERPTFEYLQAFLEDYFTST EPQYQPGENL
• Purity: Greater than 85% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [ Homo sapiens ]
• Official Symbol: SRC
• Synonyms: SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); SRC1, v src avian sarcoma (Schmidt Ruppin A 2) viral oncogene homolog; proto-oncogene tyrosine-protein kinase Src; ASV; c src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; SRC1; c-SRC; p60-Src
• Gene ID: 6714
• mRNA Refseq: NM_005417
• Protein Refseq: NP_005408
• MIM: 190090
• UniProt ID: P12931

Reviews

01/01/2022

Top-notch protein purification service, essential for our research.

08/29/2019

Reliable mass spectrometry analysis, pivotal for our proteomics work.

03/02/2019

Swift and reliable protein sequencing, indispensable for our research success.

Q&As

How do alterations in SRC expression or activity affect the development of drug resistance in tumors?

Changes in SRC expression or kinase activity can lead to drug resistance in cancer treatment.

How does SRC (proto-oncogene tyrosine-protein kinase Src) regulate cell proliferation and survival?

SRC regulates cell proliferation and survival through its kinase activity, influencing various signaling pathways.

How does SRC contribute to the regulation of bone remodeling and osteoclast activity?

SRC is involved in bone remodeling, regulating osteoclast activity and bone resorption.

What role does SRC play in cancer development and progression, particularly in metastasis?

SRC plays a crucial role in cancer progression, particularly in enhancing metastatic potential of tumor cells.

How does SRC influence cellular signaling pathways, such as the Ras/MAPK and PI3K/Akt pathways?

SRC influences key cellular signaling pathways like Ras/MAPK and PI3K/Akt, affecting cell growth and survival.

What are the mechanisms by which SRC modulates cellular adhesion and migration?

SRC modulates cellular adhesion and migration, playing a role in tissue repair and cancer metastasis.

What is the impact of SRC inhibition on targeted cancer therapies?

SRC inhibition is a target in cancer therapy, potentially reducing tumor growth and metastasis.