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Recombinant Full Length Human SRC Protein, C-Flag-tagged

Cat.No. : SRC-407HFL
Product Overview : Recombinant Full Length Human SRC Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.
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Description : This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Source : Mammalian cells
Species : Human
Tag : Flag
Form : 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 59.7 kDa
AA Sequence : MGSNKSKPKDASQRRRSLEPAENVH GAGGGAFPASQTPSKPASADGHRGP SAAFAPAAAEPKLFGGFNSS DTVTSPQRAGPLAGGVTTFVALYDY ESRTETDLSFKKGERLQIVNNTEGD WWLAHSLSTGQTGYIPSNYV APSDSIQAEEWYFGKITRRESERLL LNAENPRGTFLVRESETTKGAYCLS VSDFDNAKGLNVKHYKIRKL DSGGFYITSRTQFNSLQQLVAYYSK HADGLCHRLTTVCPTSKPQTQGLAK DAWEIPRESLRLEVKLGQGC FGEVWMGTWNGTTRVAIKTLKPGTM SPEAFLQEAQVMKKLRHEKLVQLYA VVSEEPIYIVTEYMSKGSLL DFLKGETGKYLRLPQLVDMAAQIAS GMAYVERMNYVHRDLRAANILVGEN LVCKVADFGLARLIEDNEYT ARQGAKFPIKWTAPEAALYGRFTIK SDVWSFGILLTELTTKGRVPYPGMV NREVLDQVERGYRMPCPPEC
PESLHDLMCQCWRKEPEERPTFEYL QAFLEDYFTSTEPQYQPGENLTRTR PLEQKLISEEDLAANDILDYKDDDD KV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining.
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 ug/mL as determined by microplate BCA method.
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families : Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Stem cell relevant signaling - JAK/STAT signaling pathway
Protein Pathways : Adherens junction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Focal adhesion, Gap junction, GnRH signaling pathway, Tight junction, VEGF signaling pathway
Gene Name : SRC SRC proto-oncogene, non-receptor tyrosine kinase [ Homo sapiens (human) ]
Official Symbol : SRC
Synonyms : ASV; SRC1; THC6; c-SRC; p60-Src
Gene ID : 6714
mRNA Refseq : NM_005417.5
Protein Refseq : NP_005408.1
MIM : 190090
UniProt ID : P12931

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
01/01/2022

    Top-notch protein purification service, essential for our research.

    08/29/2019

      Reliable mass spectrometry analysis, pivotal for our proteomics work.

      03/02/2019

        Swift and reliable protein sequencing, indispensable for our research success.

        Q&As (7)

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        How do alterations in SRC expression or activity affect the development of drug resistance in tumors? 10/23/2022

        Changes in SRC expression or kinase activity can lead to drug resistance in cancer treatment.

        How does SRC (proto-oncogene tyrosine-protein kinase Src) regulate cell proliferation and survival? 07/08/2021

        SRC regulates cell proliferation and survival through its kinase activity, influencing various signaling pathways.

        How does SRC contribute to the regulation of bone remodeling and osteoclast activity? 06/26/2020

        SRC is involved in bone remodeling, regulating osteoclast activity and bone resorption.

        What role does SRC play in cancer development and progression, particularly in metastasis? 03/16/2020

        SRC plays a crucial role in cancer progression, particularly in enhancing metastatic potential of tumor cells.

        How does SRC influence cellular signaling pathways, such as the Ras/MAPK and PI3K/Akt pathways? 12/06/2019

        SRC influences key cellular signaling pathways like Ras/MAPK and PI3K/Akt, affecting cell growth and survival.

        What are the mechanisms by which SRC modulates cellular adhesion and migration? 03/27/2019

        SRC modulates cellular adhesion and migration, playing a role in tissue repair and cancer metastasis.

        What is the impact of SRC inhibition on targeted cancer therapies? 01/02/2018

        SRC inhibition is a target in cancer therapy, potentially reducing tumor growth and metastasis.

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