Recombinant Full Length Human SRC Protein, C-Flag-tagged
Cat.No. : | SRC-407HFL |
Product Overview : | Recombinant Full Length Human SRC Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
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Description : | This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 59.7 kDa |
AA Sequence : | MGSNKSKPKDASQRRRSLEPAENVH GAGGGAFPASQTPSKPASADGHRGP SAAFAPAAAEPKLFGGFNSS DTVTSPQRAGPLAGGVTTFVALYDY ESRTETDLSFKKGERLQIVNNTEGD WWLAHSLSTGQTGYIPSNYV APSDSIQAEEWYFGKITRRESERLL LNAENPRGTFLVRESETTKGAYCLS VSDFDNAKGLNVKHYKIRKL DSGGFYITSRTQFNSLQQLVAYYSK HADGLCHRLTTVCPTSKPQTQGLAK DAWEIPRESLRLEVKLGQGC FGEVWMGTWNGTTRVAIKTLKPGTM SPEAFLQEAQVMKKLRHEKLVQLYA VVSEEPIYIVTEYMSKGSLL DFLKGETGKYLRLPQLVDMAAQIAS GMAYVERMNYVHRDLRAANILVGEN LVCKVADFGLARLIEDNEYT ARQGAKFPIKWTAPEAALYGRFTIK SDVWSFGILLTELTTKGRVPYPGMV NREVLDQVERGYRMPCPPEC PESLHDLMCQCWRKEPEERPTFEYL QAFLEDYFTSTEPQYQPGENLTRTR PLEQKLISEEDLAANDILDYKDDDD KV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Stem cell relevant signaling - JAK/STAT signaling pathway |
Protein Pathways : | Adherens junction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Focal adhesion, Gap junction, GnRH signaling pathway, Tight junction, VEGF signaling pathway |
Gene Name : | SRC SRC proto-oncogene, non-receptor tyrosine kinase [ Homo sapiens (human) ] |
Official Symbol : | SRC |
Synonyms : | ASV; SRC1; THC6; c-SRC; p60-Src |
Gene ID : | 6714 |
mRNA Refseq : | NM_005417.5 |
Protein Refseq : | NP_005408.1 |
MIM : | 190090 |
UniProt ID : | P12931 |
Products Types
◆ Recombinant Protein | ||
Src-6122M | Recombinant Mouse Src Protein, Myc/DDK-tagged | +Inquiry |
SRC-0402H | Recombinant Human SRC Protein (G2-L536), Tag Free | +Inquiry |
Src-907M | Active Recombinant Mouse Src protein(Met1-Leu535), His&GST-tagged | +Inquiry |
SRC-2094H | Recombinant Human SRC Protein, His (Fc)-Avi-tagged | +Inquiry |
SRC-2747H | Recombinant Human SRC Protein, MYC/DDK-tagged | +Inquiry |
◆ Native Protein | ||
SRC-29697TH | Native Human SRC | +Inquiry |
◆ Lysates | ||
SRC-487HCL | Recombinant Human SRC cell lysate | +Inquiry |
SRC-585MCL | Recombinant Mouse SRC cell lysate | +Inquiry |
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Not For Human Consumption!
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Q&As (7)
Ask a questionChanges in SRC expression or kinase activity can lead to drug resistance in cancer treatment.
SRC regulates cell proliferation and survival through its kinase activity, influencing various signaling pathways.
SRC is involved in bone remodeling, regulating osteoclast activity and bone resorption.
SRC plays a crucial role in cancer progression, particularly in enhancing metastatic potential of tumor cells.
SRC influences key cellular signaling pathways like Ras/MAPK and PI3K/Akt, affecting cell growth and survival.
SRC modulates cellular adhesion and migration, playing a role in tissue repair and cancer metastasis.
SRC inhibition is a target in cancer therapy, potentially reducing tumor growth and metastasis.
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