Active Recombinant Mouse Tgfbr2 Protein (Ile24-Asp184), mFc-tagged

Cat.No. : Tgfbr2-01M
Product Overview : Recombinant Mouse TGF-beta RII (Ile24-Asp184) Protein with Human IgG1 (Pro100-Lys330) Fc tag at C-terminus was expressed in Mouse myeloma cell line.
  • Specification
  • Gene Information
  • Related Products
  • Download
Description : Enables SMAD binding activity; transforming growth factor beta binding activity; and transforming growth factor beta-activated receptor activity. Involved in several processes, including animal organ development; circulatory system development; and positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and positive regulation of tolerance induction. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Used to study DiGeorge syndrome; Loeys-Dietz syndrome; cleft soft palate; and prostate cancer. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 2; Marfan syndrome; gastrointestinal system cancer (multiple); hereditary nonpolyposis colorectal cancer type 6; and pancreatic cancer. Orthologous to human TGFBR2 (transforming growth factor beta receptor 2).
Source : Mouse myeloma cell line
Species : Mouse
Tag : Fc
Form : Disulfide-linked homodimer
Bio-activity : Measured by its ability to inhibit TGF-beta 1 activity on HT-2 mouse T cells. The ED50 for this effect is 10-70 ng/mL.
Molecular Mass : Predicted Molecular Mass: 44.6 kDa (monomer)
SDS-PAGE: 60-65 kDa, reducing conditions
Protein length : Ile24-Asp184
N-terminal Sequence Analysis : Ile24
Endotoxin : <0.10 EU/μg of the protein by the LAL method.
Purity : >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution : Reconstitute at 100 μg/mL in sterile PBS.
Shipping : The product is shipped at ambient temperature.
Gene Name : Tgfbr2 transforming growth factor, beta receptor II [ Mus musculus (house mouse) ]
Official Symbol : Tgfbr2
Synonyms : Tgfbr2; transforming growth factor, beta receptor II; DNIIR; RIIDN; TBR-II; TbetaRII; TbetaR-II; 1110020H15Rik; TGF-beta receptor type-2; TGF-beta receptor II; TGF-beta receptor type II; TGF-beta type II receptor; TGFR-2; transforming growth factor-beta receptor type II; EC 2.7.11.30
Gene ID : 21813
mRNA Refseq : NM_009371
Protein Refseq : NP_033397
UniProt ID : Q62312

Not For Human Consumption!

Inquiry

  • Reviews
  • Q&As

Customer Reviews (3)

Write a review
Reviews
04/14/2023

    TGFBR2 protein's remarkable performance in ELISA and protein electron microscopy structure analysis positions it as a valuable tool in various fields, including cardiovascular research, developmental biology, and molecular medicine.

    12/13/2022

      TGFBR2 protein's utility extends to protein electron microscopy structure analysis, where it plays a crucial role in investigating the detailed architecture and conformational changes of proteins.

      06/25/2021

        TGFBR2 protein is highly recommended for use in various research applications, including ELISA and protein electron microscopy structure analysis.

        Q&As (5)

        Ask a question
        How is TGFBR2 linked to autoimmune diseases? 04/26/2023

        Dysregulation of TGF-beta signaling, including TGFBR2, has been associated with autoimmune diseases. Understanding these pathways may provide insights into developing targeted therapies.

        Are there clinical trials targeting TGFBR2? 01/12/2020

        Yes, there are ongoing clinical trials exploring the modulation of TGFBR2 for various conditions, including cancer and fibrotic diseases.

        How does TGFBR2 affect cardiovascular health? 12/13/2019

        TGFBR2 is involved in cardiovascular development and homeostasis. Dysregulation can contribute to conditions like aortic aneurysms and other cardiovascular diseases.

        Is TGFBR2 involved in neurological disorders? 01/14/2019

        Some studies suggest a potential link between TGFBR2 and neurological disorders. Further research is ongoing to understand its role in conditions like Alzheimer's and Parkinson's disease.

        Can TGFBR2 be a therapeutic target for fibrotic diseases? 01/19/2018

        Yes, TGFBR2 is implicated in fibrosis, and targeting it may offer therapeutic options for diseases characterized by excessive tissue scarring.

        Ask a Question for All Tgfbr2 Products

        Required fields are marked with *

        My Review for All Tgfbr2 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends