Active Recombinant Human Transforming Growth Factor, Beta Receptor II (70/80kDa)

• Cat.No.: TGFBR2-923H
• Product Overview: TGFBR2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain encoding 133 amino acids ( 27-159 a.a. ), the extracellular domain of TGFBR2, having a molecular mass of 15.1 kDa. TGFBR2 is purified by proprietary chromatographic techniques

Specification

• Cat. No.: TGFBR2-923H
• Description: TGFBR2 is part of the Ser/Thr protein kinase family and the TGFB receptor subfamily. TGFBR2 is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.
• Source: Human
• Host: Escherichia Coli.
• Form: Lyophilized from a 0.2 μm filtered solution in buffer containing 150 mM NaCl & 50 mM sodium phosphate buffer pH-7.5.
• Purity: Greater than 97.0 % as determined by SDS-PAGE.
• Bio-activity: In ELISA assay, concentrations 0.5-1 µg/ml can be used for TGF-beta measurements.
• Physical Appearance: Sterile Filtered White lyophilized ( freeze-dried ) powder.
• Solubility: It is recommended to reconstitute the lyophilized TGFBR2 in sterile 18 Mμ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
• Amino acid sequence: HVQK SVNNDMIVTD NNGAVKFPQL CKFCDVRFST CDNQKSCMSN CSITSICEKP QEVCVAVWRK NDENITLETV CHDPKLPYHD FILEDAASPK CIMKEKKKPG ETFFMCSCSS DECNDNIIFS EEYNTSNPD
• Storage: Lyophilized TGFBR2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution TGFBR2 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein ( 0.1 % HSA or BSA ). Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: TGFBR2 transforming growth factor, beta receptor II (70/80kDa) [ Homo sapiens ]
• Official Symbol: TGFBR2
• Synonyms: TGFBR2; transforming growth factor, beta receptor II (70/80kDa); AAT3; FAA3; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; TGF-beta receptor type-2; tbetaR-II; OTTHUMP00000161128; OTTHUMP00000208552; TGF-beta receptor type II; TGF-beta type II receptor; TGF-beta receptor type IIB; transforming growth factor-beta receptor type II; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II (70/80kDa) isoform 1; transforming growth factor, beta receptor II (70/80kDa) isoform 2
• Gene ID: 7048
• mRNA Refseq: NM_001024847
• Protein Refseq: NP_001020018
• MIM: 190182
• UniProt ID: P37173
• Chromosome Location: 3p22
• Pathway: ALK1 signaling events; Adherens junction; Chagas disease (American trypanosomiasis); Chronic myeloid leukemia; Colorectal cancer; Cytokine-cytokine receptor interaction; Endocytosis; Glypican 1 network; HTLV-I infection; Integrins in angiogenesis; MAPK signaling pathway; Osteoclast differentiation; Pancreatic cancer; Signaling by TGF beta; TGF-beta signaling pathway
• Function: ATP binding; SMAD binding; glycosaminoglycan binding; metal ion binding; nucleotide binding; protein binding; contributes_to protein binding; receptor activity; receptor signaling protein serine/threonine kinase activity; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor activity, type II; transmembrane receptor protein serine/threonine kinase activity; type I transforming growth factor beta receptor binding; type I transforming growth factor beta receptor binding