Active Recombinant Human TGFBR2 protein(Met1-Gln166), His-tagged
Cat.No. : | TGFBR2-377H |
Product Overview : | Recombinant Human TGFBR2 (NP_003233.4) (Met1-Gln166) was expressed in Insect Cells with a polyhistidine tag at the C-terminus. |
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Source : | Insect Cells |
Species : | Human |
Tag : | His |
Protein length : | Met1-Gln166 |
Form : | Lyophilized from sterile 20 mM PBS, 150 mM NaCl, 10 % glycerol, 0.5 mM TCEP, pH 7.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Bio-activity : | Measured by its binding ability in a functional ELISA. Immobilized TGFBR2h (1-166Q) at 10 μg/mL (100 μL/well) can bind TGFB1-His/Biotin, the EC50 of human TGFB1-His/Biotin is 130-300 ng/mL. |
Molecular Mass : | The recombinant human TGFBR2 consists of 155 amino acids and predicts a molecular mass of 17.8 kDa. As a result of glycosylation, it migrates as an approximately 24 kDa band in SDS-PAGE under reducing conditions. |
Endotoxin : | < 1.0 EU per μg protein as determined by the LAL method. |
Purity : | > 90 % as determined by SDS-PAGE. |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Gene Name : | TGFBR2 transforming growth factor, beta receptor II (70/80kDa) [ Homo sapiens ] |
Official Symbol : | TGFBR2 |
Synonyms : | TGFBR2; transforming growth factor, beta receptor II (70/80kDa); MFS2, transforming growth factor, beta receptor II (70 80kD); TGF-beta receptor type-2; tbetaR-II; TGF-beta receptor type II; TGF-beta type II receptor; TGF-beta receptor type IIB; transforming growth factor-beta receptor type II; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II (70/80kDa) isoform 1; transforming growth factor, beta receptor II (70/80kDa) isoform 2; AAT3; FAA3; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII; |
Gene ID : | 7048 |
mRNA Refseq : | NM_001024847 |
Protein Refseq : | NP_001020018 |
MIM : | 190182 |
UniProt ID : | P37173 |
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Customer Reviews (3)
Write a reviewTGFBR2 protein's remarkable performance in ELISA and protein electron microscopy structure analysis positions it as a valuable tool in various fields, including cardiovascular research, developmental biology, and molecular medicine.
TGFBR2 protein's utility extends to protein electron microscopy structure analysis, where it plays a crucial role in investigating the detailed architecture and conformational changes of proteins.
TGFBR2 protein is highly recommended for use in various research applications, including ELISA and protein electron microscopy structure analysis.
Q&As (5)
Ask a questionDysregulation of TGF-beta signaling, including TGFBR2, has been associated with autoimmune diseases. Understanding these pathways may provide insights into developing targeted therapies.
Yes, there are ongoing clinical trials exploring the modulation of TGFBR2 for various conditions, including cancer and fibrotic diseases.
TGFBR2 is involved in cardiovascular development and homeostasis. Dysregulation can contribute to conditions like aortic aneurysms and other cardiovascular diseases.
Some studies suggest a potential link between TGFBR2 and neurological disorders. Further research is ongoing to understand its role in conditions like Alzheimer's and Parkinson's disease.
Yes, TGFBR2 is implicated in fibrosis, and targeting it may offer therapeutic options for diseases characterized by excessive tissue scarring.
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