Active Recombinant Human TGFBR2 protein(Met1-Gln166), His-tagged

Cat.No. : TGFBR2-377H
Product Overview : Recombinant Human TGFBR2 (NP_003233.4) (Met1-Gln166) was expressed in Insect Cells with a polyhistidine tag at the C-terminus.
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Source : Insect Cells
Species : Human
Tag : His
Protein length : Met1-Gln166
Form : Lyophilized from sterile 20 mM PBS, 150 mM NaCl, 10 % glycerol, 0.5 mM TCEP, pH 7.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Bio-activity : Measured by its binding ability in a functional ELISA. Immobilized TGFBR2h (1-166Q) at 10 μg/mL (100 μL/well) can bind TGFB1-His/Biotin, the EC50 of human TGFB1-His/Biotin is 130-300 ng/mL.
Molecular Mass : The recombinant human TGFBR2 consists of 155 amino acids and predicts a molecular mass of 17.8 kDa. As a result of glycosylation, it migrates as an approximately 24 kDa band in SDS-PAGE under reducing conditions.
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 90 % as determined by SDS-PAGE.
Storage : Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.
Gene Name : TGFBR2 transforming growth factor, beta receptor II (70/80kDa) [ Homo sapiens ]
Official Symbol : TGFBR2
Synonyms : TGFBR2; transforming growth factor, beta receptor II (70/80kDa); MFS2, transforming growth factor, beta receptor II (70 80kD); TGF-beta receptor type-2; tbetaR-II; TGF-beta receptor type II; TGF-beta type II receptor; TGF-beta receptor type IIB; transforming growth factor-beta receptor type II; transforming growth factor beta receptor type IIC; transforming growth factor, beta receptor II (70/80kDa) isoform 1; transforming growth factor, beta receptor II (70/80kDa) isoform 2; AAT3; FAA3; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TGFR-2; TGFbeta-RII;
Gene ID : 7048
mRNA Refseq : NM_001024847
Protein Refseq : NP_001020018
MIM : 190182
UniProt ID : P37173

Not For Human Consumption!

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04/14/2023

    TGFBR2 protein's remarkable performance in ELISA and protein electron microscopy structure analysis positions it as a valuable tool in various fields, including cardiovascular research, developmental biology, and molecular medicine.

    12/13/2022

      TGFBR2 protein's utility extends to protein electron microscopy structure analysis, where it plays a crucial role in investigating the detailed architecture and conformational changes of proteins.

      06/25/2021

        TGFBR2 protein is highly recommended for use in various research applications, including ELISA and protein electron microscopy structure analysis.

        Q&As (5)

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        How is TGFBR2 linked to autoimmune diseases? 04/26/2023

        Dysregulation of TGF-beta signaling, including TGFBR2, has been associated with autoimmune diseases. Understanding these pathways may provide insights into developing targeted therapies.

        Are there clinical trials targeting TGFBR2? 01/12/2020

        Yes, there are ongoing clinical trials exploring the modulation of TGFBR2 for various conditions, including cancer and fibrotic diseases.

        How does TGFBR2 affect cardiovascular health? 12/13/2019

        TGFBR2 is involved in cardiovascular development and homeostasis. Dysregulation can contribute to conditions like aortic aneurysms and other cardiovascular diseases.

        Is TGFBR2 involved in neurological disorders? 01/14/2019

        Some studies suggest a potential link between TGFBR2 and neurological disorders. Further research is ongoing to understand its role in conditions like Alzheimer's and Parkinson's disease.

        Can TGFBR2 be a therapeutic target for fibrotic diseases? 01/19/2018

        Yes, TGFBR2 is implicated in fibrosis, and targeting it may offer therapeutic options for diseases characterized by excessive tissue scarring.

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