Recombinant Full Length Rat Tgf-Beta Receptor Type-2(Tgfbr2) Protein, His-Tagged

• Cat.No.: RFL33850RF
• Product Overview: Recombinant Full Length Rat TGF-beta receptor type-2(Tgfbr2) Protein (P38438) (24-567aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Rattus norvegicus (Rat)
• Tag: His
• Form: Lyophilized powder
• Protein length: Full Length of Mature Protein (24-567)
• AA Sequence: IPPHVPKSVNSDLMAGDNSGAVKLP QLCKFCDVTLSTCDNQKSCMSNCSV TSICEKPQEVCVAVWRKNDKNITLE TVCHDPKFTYHGFTLEDATSPTCVM KEKKRAGETFFMCSCNTEECNDYII FNEEYTTSSPDLLLVIIQVTGVSLL PPLGIAIAVIAIFYCYRVHRQQKLS PSWESSKPRKLMDFSDNCAIILEDD RSDISSTCANNINHNTELLPIELDT LVGKGRFAEVYKAKLKQNTSEQFET VAVKIFPYEEYSSWKTEKDIFSDIN LKHENILQFLTAEERKTEMGKQYWL ITAFHAKGNLQEYLTRHVISWEDLR KLGSSLARGIAHLHSDHTPCGRPKM PIVHRDLKSSNILVKNDLTCCLCDF GLSLRLDPTLSVDDLANSGQVGTAR YMAPEVLESRMNLENMESFKQTDVY SMALVLWEMTSRCNAVGEVKDYEPP FGSKVREHPCVESMKDNVLRDRGRP EIPSFWLNHQGIQIVCETLTECWDH DPEARLTAQCVAERFSELEHPDRLS GRSCSQEKIPEDGSLNTTK
• Purity: Greater than 90% as determined by SDS-PAGE.
• Applications: SDS-PAGE
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: Tgfbr2
• Synonyms: Tgfbr2; TGF-beta receptor type-2; TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II
• UniProt ID: P38438

Gene Information

• Gene Name: Tgfbr2
• Synonyms: Tgfbr2; TGF-beta receptor type-2; TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TGF-beta receptor type II; TbetaR-II
• UniProt ID: P38438

Reviews

04/14/2023

TGFBR2 protein's remarkable performance in ELISA and protein electron microscopy structure analysis positions it as a valuable tool in various fields, including cardiovascular research, developmental biology, and molecular medicine.

12/13/2022

TGFBR2 protein's utility extends to protein electron microscopy structure analysis, where it plays a crucial role in investigating the detailed architecture and conformational changes of proteins.

06/25/2021

TGFBR2 protein is highly recommended for use in various research applications, including ELISA and protein electron microscopy structure analysis.

Q&As

How is TGFBR2 linked to autoimmune diseases?

Dysregulation of TGF-beta signaling, including TGFBR2, has been associated with autoimmune diseases. Understanding these pathways may provide insights into developing targeted therapies.

Are there clinical trials targeting TGFBR2?

Yes, there are ongoing clinical trials exploring the modulation of TGFBR2 for various conditions, including cancer and fibrotic diseases.

How does TGFBR2 affect cardiovascular health?

TGFBR2 is involved in cardiovascular development and homeostasis. Dysregulation can contribute to conditions like aortic aneurysms and other cardiovascular diseases.

Is TGFBR2 involved in neurological disorders?

Some studies suggest a potential link between TGFBR2 and neurological disorders. Further research is ongoing to understand its role in conditions like Alzheimer's and Parkinson's disease.

Can TGFBR2 be a therapeutic target for fibrotic diseases?

Yes, TGFBR2 is implicated in fibrosis, and targeting it may offer therapeutic options for diseases characterized by excessive tissue scarring.