| Description : |
The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
Flag |
| Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Molecular Mass : |
62 kDa |
| AA Sequence : |
MGRGLLRGLWPLHIVLWTRIASTIP PHVQKSVNNDMIVTDNNGAVKFPQL CKFCDVRFSTCDNQKSCMSN CSITSICEKPQEVCVAVWRKNDENI TLETVCHDPKLPYHDFILEDAASPK CIMKEKKKPGETFFMCSCSS DECNDNIIFSEEYNTSNPDLLLVIF QVTGISLLPPLGVAISVIIIFYCYR VNRQQKLSSTWETGKTRKLM EFSEHCAIILEDDRSDISSTCANNI NHNTELLPIELDTLVGKGRFAEVYK AKLKQNTSEQFETVAVKIFP YEEYASWKTEKDIFSDINLKHENIL QFLTAEERKTELGKQYWLITAFHAK GNLQEYLTRHVISWEDLRKL GSSLARGIAHLHSDHTPCGRPKMPI VHRDLKSSNILVKNDLTCCLCDFGL SLRLDPTLSVDDLANSGQVG TARYMAPEVLESRMNLENVESFKQT DVYSMALVLWEMTSRCNAVGEVKDY EPPFGSKVREHPCVESMKDN VLRDRGRPEIPSFWLNHQGIQMVCE TLTECWDHDPEARLTAQCVAERFSE LEHLDRLSGRSCSEEKIPED
GSLNTTKSGPTRTRRLEQKLISEED LAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Families : |
Druggable Genome, Protein Kinase, Transmembrane |
| Protein Pathways : |
Adherens junction, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Endocytosis, MAPK signaling pathway, Pancreatic cancer, Pathways in cancer, TGF-beta signaling pathway |
