Active Recombinant Human TNFRSF10B protein, Fc-tagged, FITC-labeled

• Cat.No.: TNFRSF10B-56H
• Product Overview: Recombinant Human TNFRSF10B(aa 52-212) fused with the Fc portion of human IgG1 was expressed in HEK293, FITC conjugate.

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Protein Length: 52-212 a.a.
• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.
• Form: Liquid. In PBS containing 0.02% sodium azide.
• Bio-activity: Inhibits human soluble TRAIL-mediated apoptosis.
• Molecular Mass: ~46kDa (SDS-PAGE).
• Endotoxin: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
• Purity: ≥95% (SDS-PAGE)
• Applications: Flow Cytometry: detection of TRAIL cell surface expression.
• Stability: Stable for at least 6 months after receipt when stored at -20 centigrade.
• Storage: Long Term Storage: -20 centigrade. Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20 centigrade.
• Concentration: 1mg/ml
• Conjugation: FITC

Gene Information

• Gene Name: TNFRSF10B tumor necrosis factor receptor superfamily, member 10b [ Homo sapiens ]
• Official Symbol: TNFRSF10B
• Synonyms: TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor superfamily member 10B; CD262; DR5; KILLER; TRAIL R2; TRICK2A; TRICKB; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor(killer); TRICK2; ZTNFR9; TRAILR2; TRICK2B; TRAIL-R2; KILLER/DR5
• Gene ID: 8795
• mRNA Refseq: NM_003842
• Protein Refseq: NP_003833
• MIM: 603612
• UniProt ID: O14763
• Chromosome Location: 8p22-p21
• Pathway: Activation of Pro-Caspase 8, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; Caspase-8 is formed from procaspase-8, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem
• Function: TRAIL binding; protein binding; receptor activity