Recombinant Human TNFRSF10B protein, Fc-tagged
Cat.No. : | TNFRSF10B-377H |
Product Overview : | Recombinant Human TNFRSF10B protein (Ile56-Glu182), fused to human IgG1 Fc tag at C-terminus, was expressed in human 293 cells (HEK293). |
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- Gene Information
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Description : | Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B/DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2/CD262/ DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2/TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262/DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53. |
Source : | HEK293 |
Species : | Human |
Tag : | human IgG1 Fc |
Form : | Lyophilized from 0.22 um filtered solution in 50 mM Tris, 100 mM NaCl, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 40.5 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | 127 |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | TNFRSF10B |
Official Symbol : | TNFRSF10B |
Synonyms : | TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor superfamily member 10B; CD262; DR5; KILLER; TRAIL R2; TRICK2A; TRICKB; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor(killer); TRICK2; ZTNFR9; TRAILR2; TRICK2B; TRAIL-R2; KILLER/DR5 |
Gene ID : | 8795 |
mRNA Refseq : | NM_003842 |
Protein Refseq : | NP_003833 |
MIM : | 603612 |
UniProt ID : | O14763 |
Products Types
◆ Recombinant Protein | ||
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Tnfrsf10b-2745R | Recombinant Rat Tnfrsf10b Protein, His-tagged | +Inquiry |
Tnfrsf10b-6544M | Recombinant Mouse Tnfrsf10b Protein, Myc/DDK-tagged | +Inquiry |
TNFRSF10B-1148H | Recombinant Human TNFRSF10B Protein (Met1-Glu182), HlgG1 Fc-tagged | +Inquiry |
◆ Lysates | ||
TNFRSF10B-2829HCL | Recombinant Human TNFRSF10B cell lysate | +Inquiry |
TNFRSF10B-2397MCL | Recombinant Mouse TNFRSF10B cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionActivation of TNFRSF10B triggers apoptotic pathways, leading to programmed cell death in cancer cells.
TNFRSF10B has been implicated in certain autoimmune diseases and neurodegenerative disorders, highlighting its diverse roles in various physiological processes.
TNFRSF10B expression levels may serve as a potential diagnostic marker for certain cancers, aiding in cancer detection and prognosis.
TNFRSF10B expression is often altered in various cancers, including breast cancer, colorectal cancer, and lung cancer.
Side effects may occur, and ongoing research aims to minimize these effects while maximizing the therapeutic benefits of targeting TNFRSF10B.
Customer Reviews (3)
Write a reviewThe combination of high-quality TNFRSF10B protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.
The manufacturer's extensive experience and expertise in the field of TNFRSF10B protein research make them a trusted partner.
The manufacturer's commitment to providing excellent technical support is highly valuable.
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