Recombinant Human TNFRSF10B Protein, His-tagged

• Cat.No.: TNFRSF10B-462H
• Product Overview: Recombinant human TNFRSF10B protein with His tag was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.
• Source: HEK293
• Species: Human
• Tag: His
• Form: Lyophilized
• Molecular Mass: 15.1 kDa
• Protein Length: 440
• AA Sequence: MEQRGQNAPAASGARKRHGPGPREA RGARPGPRVPKTLVLVVAAVLLLVS AESALITQQDLAPQQRAAPQQKRSS PSEGLCPPGHHISEDGRDCISCKYG QDYSTHWNDLLFCLRCTRCDSGEVE LSPCTTTRNTVCQCEEGTFREEDSP EMCRKCRTGCPRGMVKVGDCTPWSD IECVHKESGTKHSGEVPAVEETVTS SPGTPASPCSLSGIIIGVTVAAVVL IVAVFVCKSLLWKKVLPYLKGICSG GGGDPERVDRSSQRPGAEDNVLNEI VSILQPTQVPEQEMEVQEPAEPTGV NMLSPGESEHLLEPAEAERSQRRRL LVPANEGDPTETLRQCFDDFADLVP FDSWEPLMRKLGLMDNEIKVAKAEA AGHRDTLYTMLIKWVNKTGRDASVH TLLDALETLGERLAKQKIEDHLLSS GKFMYLEGNADSAMS
• Purity: > 98%
• Applications: WB; ELISA; FACS; FC
• Stability: This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
• Storage: At -20 centigrade.
• Concentration: 1 mg/mL
• Storage Buffer: PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
• Reconstitution: Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.

Gene Information

• Gene Name: TNFRSF10B tumor necrosis factor receptor superfamily, member 10b [ Homo sapiens (human) ]
• Official Symbol: TNFRSF10B
• Synonyms: TNFRSF10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor superfamily member 10B; CD262; DR5; KILLER; TRAIL R2; TRICK2A; TRICKB; Fas-like protein; death receptor 5; cytotoxic TRAIL receptor-2; apoptosis inducing receptor TRAIL-R2; apoptosis inducing protein TRICK2A/2B; TNF-related apoptosis-inducing ligand receptor 2; death domain containing receptor for TRAIL/Apo-2L; tumor necrosis factor receptor-like protein ZTNFR9; p53-regulated DNA damage-inducible cell death receptor(killer); TRICK2; ZTNFR9; TRAILR2; TRICK2B; TRAIL-R2; KILLER/DR5
• Gene ID: 8795
• mRNA Refseq: NM_003842
• Protein Refseq: NP_003833
• MIM: 603612
• UniProt ID: O14763