Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

UCH-L3 Deubiquitinase Inhibitor Screening Kit

Cat.No. : Kit-2390
Product Overview : Diseases such as cancer and Alzehimer’s are often the result of dysregulation of proteostasis. Protein levels in the cell are regulated by both synthesis and degradation, with some proteins being marked for either localization or proteasomal degradation through the attachment of ubiquitin, a small, 76-amino acid protein. This attachment, termed ‘ubiquitination,’ or ‘ubiquitylation’ can be reversed by enzymes known as deubiquitinases (DUBs). The human proteome includes as many as four hundred DUBs, and thus these enzymes offer more specific targets for altering cellular equilibrium. UCH-L3, a DUB, is a cysteine protease that has been implicated in prostate cancer, although its regulation and downstream targets are largely unknown. It has been found that UCH-L3 is a novel regulator of epithelial-to-mesenchymal transition in cancer cell metastasis, making it an attractive drug target. Unfortunately, specific inhibitors for this and other DUBs are not readily available. Such compounds would also be a necessity for further illuminating and understanding downstream signaling.UCH-L3 Inhibitor Screening Kit utilizes the ability of active human UCH-L3 deubiquitinase to cleave a synthetic DUB substrate to release a fluorophore, which can be easily quantified (Ex/Em = 360/460 nm) using a fluorescence microplate reader. This inhibitor screening kit thus allows rapid and reliable determination of the inhibitory effects of various compounds on UCH-L3 deubiquitinase and could be used to screen for novel inhibitors. A nonspecific DUB inhibitor is included in this kit to allow the user to validate the experimental setup.
  • Specification
  • Gene Information
  • Related Products
Applications : Screening/characterizing/studying UCH-L3 inhibitors/activators
Storage : -20°C
Size : 100 assays

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All UCH-L3 Products

Required fields are marked with *

My Review for All UCH-L3 Products

Required fields are marked with *

0

Inquiry Basket

cartIcon
logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends