Active Recombinant Full Length Human ADAR Protein, Flag tagged

• Cat.No.: ADAR-12HFL
• Product Overview: Recombinant human ADAR1 (adenosine deaminase, RNA-specific 1) transcript 1, full length encompassing amino acids 2-1226 (end). This construct contains an N-terminal FLAG-tag. The recombinant protein was affinity purified.

Specification

• Species: Human
• Source: HEK293
• Tag: Flag
• Protein Length: 2-1226 aa
• Description: ADAR1 (adenosine deaminase, RNA-specific 1) performs adenosine to inosine base editing in RNA, particularly targeting adenosines located within a specific stem-loop motif structure. It is proposed that ADARs evolved to provide additional diversity to the transcriptome and while the majority of ADAR editing events occur in non-coding RNAs, some, including the canonical GluA2 editing site, alter the amino acid sequence of coding proteins. ADAR1 plays a role in innate immunity by mitigating interferon signaling. Dysfunction of ADAR1 results in autoimmune disorders, and impacts cancer cell growth and proliferation as well as tumor response to immunotherapy. Since ADAR recognizes double-stranded RNA, it also functions to suppress or modify RNA viruses. Thus, it is implicated in viral evolution and in the emergence of viral variants such as SARS-CoV-2 variants.
• Form: Aqueous buffer solution
• Molecular Mass: 137 kDa
• Purity: ≥70%
• Storage: At least 6 months at –80 centigrade.
• Storage Buffer: 50 mM Tris-HCl, pH 8.0, 750 mM NaCl, 0.01% Triton X-100, 10% glycerol and variable FLAG peptide.
• Concentration: 0.77 mg/mL
• Shipping: At -80 centigrade.

Gene Information

• Gene Name: ADAR adenosine deaminase, RNA-specific [ Homo sapiens (human) ]
• Official Symbol: ADAR
• Synonyms: ADAR; adenosine deaminase, RNA-specific; G1P1, IFI4, interferon induced protein 4; double-stranded RNA-specific adenosine deaminase; ADAR1; dsRNA adenosine deaminase; interferon-induced protein 4; interferon-inducible protein 4; adenosine deaminase acting on RNA 1-A; 136 kDa double-stranded RNA-binding protein; DSH; G1P1; IFI4; P136; DRADA; DSRAD; IFI-4; K88DSRBP
• Gene ID: 103
• mRNA Refseq: NM_001111
• Protein Refseq: NP_001102
• MIM: 146920
• UniProt ID: P55265