| Species : |
Human |
| Source : |
CHO |
| Tag : |
HA |
| Protein Length : |
50-224 aa |
| Description : |
Predicted to be involved in maintenance of synapse structure and spontaneous synaptic transmission. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in synaptic cleft. Predicted to be part of trans-synaptic protein complex. Predicted to be active in glutamatergic synapse. |
| Bio-activity : |
Measured by its binding ability in a functional ELISA. When Recombinant Human Cerebellin-2 is coated at 5 μg/mL, biotinylated recombinant rat NRXN-1 beta binds with an apparent KD <1.5 nM. Measured by its ability to enhance neurite outgrowth of E16-E18 rat embryonic cortical neurons. Recombinant Human Cerebellin-2, immobilized at 3-30 μg/mL, is able to significantly enhance neurite outgrowth. |
| N-terminal Sequence Analysis : |
Tyr |
| Molecular Mass : |
20 kDa |
| Endotoxin : |
< 1 EU/μg of protein (determined by LAL method) |
| Purity : |
> 85%, by SDS-PAGE under reducing conditions and visualized by silver stain |
| Storage : |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
| Storage Buffer : |
Lyophilized from a 0.2 μm filtered solution in PBS. |
| Reconstitution : |
Reconstitute at 200 μg/mL in PBS. |
| Shipping : |
The product is shipped at ambient temperature. |
| Reference : |
1. Yuzaki, M. (2011) Curr. Opin. Neurobiol. 21:215.
2. Kavety, B. et al. (1994) Brain Res. Mol. Brain Res. 27:152.
3. Wada, C. and H. Ohtani (1991) Brain Res. Mol. Brain Res. 9:71. |
