| Description : |
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
DDK |
| Form : |
50mM Tris-HCl pH8.0, 100mM glycine, 10% glycerol. |
| Bio-activity : |
Binding assay |
| Molecular Mass : |
59 kDa |
| AA Sequence : |
A DNA sequence from TrueORF clone, RC218519, encoding human full-length ESR2. |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Protein Families : |
Druggable Genome, Nuclear Hormone Receptor, Transcription Factors |
