Active Recombinant Full Length Human PPP2CA and PPP2R1A complex, N-His tagged
| Cat.No. : | PPP2CA-PPP2R1A-10HFL |
| Product Overview : | Recombinant full length human PP2Aa and human PPP2R1A were expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. The PP2Aa gene accession number is NM_002715; PPP2R1A is NM_014225. |
- Specification
- Gene Information
- Related Products
| Description : | PP2A alpha is also known as Protein phosphatase 2A active subunit. PP2A is one of the four major Ser/Thr phosphatases and is a human tumor suppressor that inhibits cellular transformation. PP2A alpha gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase-2A. Protein phosphatase 2A holoenzyme is a heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. PTP2A alpha can alter the substrate specificity of PP2A leading to enhanced phosphotyrosine phosphatase activity and decreased phosphoserine phosphatase activity. |
| Source : | Sf9 insect cells |
| Species : | Human |
| Tag : | N-His |
| Protein length : | Full length |
| Bio-activity : | 4,000 nmol/min/mg |
| Molecular Mass : | PP2Aalpha: ~38 kDa PPP2R1A: ~65 kDa |
| Purity : | >75% |
| Stability : | 1 year at –70 centigrade from date of shipment |
| Storage : | Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Concentration : | 0.1 μg/μL |
| Storage Buffer : | Recombinant protein stored in 50mM MOPS, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. |
| Shipping : | Dry ice |
| References : | 1. Van Hoof, C. et.al: Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A. Genomics 28: 261-272, 1995. 2. Chao, Y. et.al: Structure and mechanism of the phosphotyrosyl phosphatase activator. Molec. Cell 23: 535-546, 2006. |
| Gene Name : | PPP2CA protein phosphatase 2 catalytic subunit alpha [ Homo sapiens (human) ] |
| Official Symbol : | PPP2CA |
| Synonyms : | PPP2CA; protein phosphatase 2 catalytic subunit alpha; HJS3; RP-C; PP2Ac; PP2CA; NEDLBA; PP2Calpha; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha; protein phosphatase 2, catalytic subunit, alpha isozyme; replication protein C; EC 3.1.3.16; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; Names; medium tumor antigen-associated 61 KDA protein; protein phosphatase 2, regulatory subunit A, alpha; testicular secretory protein Li 1; EC 3.1.3.16; PPP2R1A; protein phosphatase 2 scaffold subunit Aalpha; HJS2; MRD36; PP2AA; PR65A; PP2AAALPHA; PP2A-Aalpha |
| Gene ID : | 5515 |
| mRNA Refseq : | NM_002715 |
| Protein Refseq : | NP_002706 |
| MIM : | 176915 |
| UniProt ID : | P05323 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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