| Species : |
Human |
| Source : |
E.coli |
| Tag : |
Non |
| Protein Length : |
1-140 aa |
| Description : |
Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration. |
| Form : |
Supplied as 0.2 μm filtered solution in PBS, pH7.4 with trehalose as protectant. |
| Specificity : |
Sterility: Negative |
| Bio-activity : |
Thioflavin T emission curves show increased fluorescence (correlated to alpha-syn aggregation) over time when alpha-syn wild-type monomers are combined with tau wild-type Pre-formed Fibrils. |
| Molecular Mass : |
The protein has a calculated MW of 14.5 kDa. |
| Endotoxin : |
Less than 1.0 EU/μg by the LAL method/rFC method. |
| Purity : |
>90% as determined by SDS-PAGE. |
| Storage : |
This product is stable after storage at: The product should be stored at -70 centigrade or room temperature for short storage. Do not store fibrils on ice or at 4 centigrade; The unsonicated fibril is validated to be stable after storage at -70 centigrade for 1 year under sterile conditions; The sonicated fibril should be stored at -70 centigrade for not more than 8 weeks. Please avoid repeated freeze-thaw cycles. |
| Concentration : |
0.2 mg/mL |
| Shipping : |
This product is supplied and shipped with dry ice, please inquire the shipping cost. |
