Active Recombinant Full Length Human TIMP4 Protein

• Cat.No.: TIMP4-10HFL
• Product Overview: Active Recombinant Full Length Human TIMP4 Protein was expressed in insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: Non
• Protein Length: 30-224 aa
• Description: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.
• Form: Lyophilized from a 0.2 μm filtered solution in Tris and NaCl.
• Bio-activity: Measured by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2. The IC50 value is approximately 2.5 nM.
• Molecular Mass: 22 kDa
• Endotoxin: < 1.0 EU/μg of the protein by the LAL method.
• Purity: > 95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 centigrade as supplied. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
• Shipping: The product is shipped with polar packs.
• Reconstitution: Reconstitute at 200 μg/mL in sterile, deionized water.
• N-terminal Sequence Analysis: Cys30

Gene Information

• Gene Name: TIMP4 TIMP metallopeptidase inhibitor 4 [ Homo sapiens (human) ]
• Official Symbol: TIMP4
• Synonyms: TIMP4; TIMP metallopeptidase inhibitor 4; tissue inhibitor of metalloproteinase 4; metalloproteinase inhibitor 4; TIMP-4; tissue inhibitor of metalloproteinases 4
• Gene ID: 7079
• mRNA Refseq: NM_003256
• Protein Refseq: NP_003247
• MIM: 601915
• UniProt ID: Q99727