Active Recombinant Human ACVR1 Protein, His-Fc-tagged

• Cat.No.: ACVR1-527H
• Product Overview: Active Recombinant Human ACVR1 Protein(Met 1-Val 124)(NP_001104537.1) precursor was expressed in HEK293, fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Specification

• Species: Human
• Source: HEK293
• Tag: Fc&His
• Protein Length: 1-124 aa
• Form: Lyophilized from sterile PBS, pH 7.4.
• Bio-activity: Measure by its ability to bind with human BMP2 in a functional ELISA.
• Molecular Mass: The recombinant human ALK2/Fc is a disulfide-linked homodimeric Protein after removal of the signal peptide. Each monomer consists of 352 amino acids and predicts a molecular mass of 39.6 kDa. As a result of glycosylation, the rh ALK2/Fc monomer migrates as approximately 40-45 kDa band in SDS-PAGE under reducing conditions.
• Endotoxin: < 1 EU/µg as determined by LAL test.
• Purity: > 95 % as determined by SDS-PAGE
• Storage: Store it under sterile conditions at -20°C to -80°C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: ACVR1 activin A receptor, type I [ Homo sapiens ]
• Official Symbol: ACVR1
• Synonyms: ACVR1; activin A receptor, type I; ACVRLK2; activin receptor type-1; ACVR1A; ALK2; SKR1; activin receptor type I; hydroxyalkyl-protein kinase; activin receptor-like kinase 2; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 2; serine/threonine-protein kinase receptor R1; FOP; TSRI; ACTRI
• Gene ID: 90
• mRNA Refseq: NM_001105
• Protein Refseq: NP_001096
• MIM: 102576
• UniProt ID: Q04771