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Active Recombinant Human Calmodulin 1 (Phosphorylase Kinase, Delta)

Cat.No. : CALM1-88H
Product Overview : Recombinant Human Calmodulin full length protein expressed inE.coli.
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  • Gene Information
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Cat. No. : CALM1-88H
Description : Calmodulin (CaM) is an intracellular receptor protein for Ca2+-ions. It activates the myosin light chain kinase which is the catalyst of myosin phosphorylation. CaM participates in the activation of enzymes such as cyclic nucleotide- dependent phosphodiesterase, calcineurin, ATPase, Myosin Light Chain Kinases, and CAM kinase.
Source : Escherichia Coli.
Physical Appearance : Sterile Filtered clear solution.
Purity : Greater than 90% as determined by SDS-PAGE.
Formulation : Calmodulin at 1mg/ml in 20mM HEPES-KOH, pH7, 50mM NaCl, 1mM EDTA and 1mM DTT.
Activity : Assayed for calcium binding and activation of MLCK.
Applications : • ELISA • Inhibition Assays • Western Blotting
Storage : Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please prevent freeze-thaw cycles.
Gene Name : CALM1 calmodulin 1 (phosphorylase kinase, delta) [ Homo sapiens ]
Synonyms : CALM1; calmodulin 1 (phosphorylase kinase, delta); CAMI; PHKD; DD132; CALML2; calmodulin 1; phosphorylase kinase, delta subunit; EC 2.7.11.19; CALMCAM; CAM1; CAM2; CAM3; CAMB; CAMC; CAMIII; CaM
Gene ID : 801
mRNA Refseq : NM_001166106
Protein Refseq : NP_001159578
MIM : 114180
UniProt ID : P62158
Chromosome Location : 14q24-q31
Pathway : Alzheimer"s disease; Calcium signaling pathway; Glioma; GnRH signaling pathway; Insulin signaling pathway; Long-term potentiation; Melanogenesis; Neurotrophin signaling pathway; Olfactory transduction; Phosphatidylinositol signaling system; Vascular smooth muscle contraction

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What are the primary functions of CALM1 in cells and biological systems? 02/02/2022

CALM1 plays a crucial role in mediating calcium-dependent signaling pathways, influencing processes such as muscle contraction, neurotransmitter release, and gene expression.

What are the laboratory methods used to analyze CALM1's interactions with target proteins and the implications for drug development and disease research? 04/04/2021

Techniques like co-immunoprecipitation and fluorescence resonance energy transfer (FRET) are used to study CALM1's interactions. This knowledge is crucial for drug development and disease research.

What is the chemical structure of CALM1, and how does it interact with calcium ions? 11/23/2020

CALM1 is a small calcium-binding protein. It undergoes conformational changes upon binding calcium ions, allowing it to regulate various cellular processes.

What is the relationship between CALM1 and neuronal excitability, particularly in the context of calcium channel regulation and neurotransmitter release? 12/29/2018

CALM1 modulates neuronal excitability by regulating calcium channels and neurotransmitter release. It is crucial for normal neuronal function.

How does CALM1 modulate the activity of enzymes and cellular proteins in a calcium-dependent manner, and what is the significance of this regulation? 09/24/2018

CALM1 binds to and activates various enzymes and proteins in response to changes in calcium levels, regulating diverse cellular functions and maintaining homeostasis.

Customer Reviews (3)

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Reviews
01/05/2022

    The quality of the product is unmatched, and it's worth every penny.

    04/29/2021

      The product simplifies my workflow, saving me time and effort.

      02/09/2019

        I've recommended the product to all my colleagues; it's that good.

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