Active Recombinant Human CASK, GST-tagged

• Cat.No.: CASK-1375H
• Product Overview: Recombinant human CASK (1-570) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: CASK is a calcium/calmodulin-dependent serine protein kinase which is a MAGUK (membrane-associated guanylate kinase) protein family member. CASK is a scaffold protein and the encoded protein is located at synapses in the brain. CASK associates with FG syndrome 4, mental retardation, microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. CASK functions as a cytoskeletal membrane scaffold that coordinates signal transduction pathways within the cortical cytoskeleton.
• Source: Sf9 Cells
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 3 nmol/min/mg
• Molecular Mass: ~95 kDa
• Protein length: 1-570 aa
• Purity: >95%
• Applications: Kinase Assay, Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) [ Homo sapiens ]
• Official Symbol: CASK
• Synonyms: CASK; calcium/calmodulin-dependent serine protein kinase (MAGUK family); TNRC8, trinucleotide repeat containing 8; peripheral plasma membrane protein CASK; CAGH39; FGS4; LIN2; hCASK; protein lin-2 homolog; trinucleotide repeat containing 8; calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase; CMG; TNRC8; CAMGUK; MICPCH; MRXSNA; FLJ22219; FLJ31914
• Gene ID: 8573
• mRNA Refseq: NM_001126054
• Protein Refseq: NP_001119526
• MIM: 300172
• UniProt ID: O14936
• Chromosome Location: Xp11.4
• Pathway: Cell-Cell communication, organism-specific biosystem; Nephrin interactions, organism-specific biosystem; Syndecan-1-mediated signaling events, organism-specific biosystem; Syndecan-2-mediated signaling events, organism-specific biosystem; Syndecan-3-mediated signaling events, organism-specific biosystem; Tight junction, organism-specific biosystem; Tight junction, conserved biosystem
• Function: ATP binding; calmodulin binding; guanylate kinase activity; nucleotide binding; protein binding; protein serine/threonine kinase activity