Active Recombinant Human CCL23 Protein (92 aa)

• Cat.No.: CCL23-296C
• Product Overview: Recombinant human Ck beta 8-1/CCL23 produced in CHO cells is a single polypeptide chain containing 92 amino acids. A fully biologically active molecule, rhCk beta 8-1/CCL23 has a molecular mass of 10.5 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.

Specification

• Description: Chemokine (C-C motif) ligand 23 (CCL23) is a small cytokine belonging to the CC chemokine family that is also known as Macrophage inflammatory protein 3 (MIP-3) and Myeloid progenitor inhibitory factor 1 (MPIF-1). CCL23 is predominantly expressed in lung and liver tissue, but is also found in bone marrow and placenta.CCL23 is highly chemotactic for resting T cells and monocytes and slightly chemotactic for neutrophils. It has also been attributed to an inhibitory activity on hematopoietic progenitor cells. CCL23 is a ligand for the chemokine receptor CCR1.
• Source: CHO
• Species: Human
• Form: Sterile Filtered White lyophilized (freeze-dried) powder.
• Bio-activity: The EC50 value of human Ck beta 8-1/CCL23 on Ca^2+ mobilization assay in CHO-K1/Ga15/hCCR1 cells (human Ga15 and human CCR1 stably expressed in CHO-K1 cells) is less than 0.4 μg/mL.
• Molecular Mass: 10.5 kDa, observed by reducing SDS-PAGE.
• Protein Length: 92
• AA Sequence: MLWRRKIGPQMTLSHAAGFHATSAD CCISYTPRSIPCSLLESYFETNSEC SKPGVIFLTKKGRRFCANPSDKQVQ VCVRMLKLDTRIKTRKN
• Endotoxin: < 0.2 EU/μg, determined by LAL method.
• Purity: > 98% as analyzed by SDS-PAGE.
• Storage: Lyophilized recombinant human Ck beta 8-1/CCL23 remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, human Ck beta 8-1/CCL23 should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade.
• Storage Buffer: Lyophilized after extensive dialysis against PBS.
• Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Gene Information

• Gene Name: CCL23 chemokine (C-C motif) ligand 23 [ Homo sapiens ]
• Official Symbol: CCL23
• Synonyms: CCL23; chemokine (C-C motif) ligand 23; SCYA23, small inducible cytokine subfamily A (Cys Cys), member 23; C-C motif chemokine 23; Ckb 8; CKb8; MIP 3; MPIF 1; hmrp-2a; C6 beta-chemokine; small-inducible cytokine A23; macrophage inflammatory protein 3; myeloid progenitor inhibitory factor 1; small inducible cytokine subfamily A (Cys-Cys), member 23; MIP3; Ckb-8; MIP-3; MPIF-1; SCYA23; Ckb-8-1; CK-BETA-8
• Gene ID: 6368
• mRNA Refseq: NM_005064
• Protein Refseq: NP_005055
• MIM: 602494
• UniProt ID: P55773