Active Recombinant Human CD83, HIgG1 Fc-tagged, mutant
Cat.No. : | CD83-2065H |
Product Overview : | The extracellular domain of human CD83 (NP_004224.1) (Thr20-Ala131) is fused to the N-terminus of the Fc region of a mutant human IgG1 was expressed in CHO cell. |
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Description : | The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene |
Source : | CHO cells |
Species : | Human |
Tag : | HIgG1 Fc-tagged, mutant |
Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
Bio-activity : | Measured by the ability of the immobilized protein to support the adhesion of human monocyte-derived dendritic cells. |
Molecular Mass : | 41 KDa (monomer) |
AA Sequence : | Thr20-Ala131 |
Endotoxin : | <0.06 eu/μg as determined by lal test.>0.06> |
Purity : | >98%, by SDS-PAGE under reducing conditions. |
Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
Warning : | Avoid freeze/thaw cycles. |
Protein length : | Thr20-Ala131 |
Gene Name : | CD83 CD83 molecule [ Homo sapiens ] |
Official Symbol : | CD83 |
Synonyms : | CD83; CD83 molecule; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily) , CD83 molecule; CD83 antigen; BL11; HB15; hCD83; B-cell activation protein; cell surface protein HB15; cell-surface glycoprotein; CD83 antigen (activated B lymphocytes, immunoglobulin superfamily); |
Gene ID : | 9308 |
mRNA Refseq : | NM_001040280 |
Protein Refseq : | NP_001035370 |
MIM : | 604534 |
UniProt ID : | Q01151 |
Chromosome Location : | 6p23 |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewThe experimental conditions are wide, and the experimental results are accurate and reproducible.
The resulting strips are clear and bright, which greatly exceeds the expected results.
CD83 activity is maintained for a very long time and can be maintained for a long time, which is very stable and reliable.
Q&As (6)
Ask a questionYes, CD83 can be targeted as immunotherapy. Immunotherapy for CD83 has been explored in several clinical trials with some efficacy.
It is unclear whether there is a population difference in CD83 treatment. However, due to factors such as individual differences and genetic polymorphisms, different populations may respond differently to treatment. Therefore, population-specific treatment strategies may need to be individually adapted and optimized.
Future research on CD83 may involve more in-depth molecular mechanism studies, optimization and improvement of CD83-based immunotherapy strategies, and research on combination with other immunotherapies or drugs.
CD83 interacts and regulates with other immune checkpoint molecules. Together, they are involved in the regulation of the immune response.
Yes, CD83 expression is regulated by a variety of molecules, including cytokines, transcription factors, and epigenetic modifications.
Current treatments for CD83 mainly include immunotherapy and gene therapy. Immunotherapy against CD83 works primarily by modulating the function of dendritic cells and T cells.
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