Active Recombinant Human Chemokine (C-X-C motif) Ligand 17 CXCL17-436H

Active Recombinant Human Chemokine (C-X-C motif) Ligand 17


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Active Recombinant Human Chemokine (C-X-C motif) Ligand 17

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Cat.No. : CXCL17-436H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Human CXCL17is expressed in E. coli, which has a molecule weight of 11.3 kDa. Leu24­ Leu119.
Description : Dendritic cell and monocytechemokine­like protein (DMC), also known as VEGF­correlated chemokine­1 (VCC­1)and CXCL17, is a novel secreted molecule that belongs to the intercrine alpha(or CXC) family of chemokines. It has no predicted N­glycosylation sites, so cleavageof a 22 amino acid (aa) signal sequence likely results in a mature human DMC of97 aa and 11 kDa. DMC expression is increased in endothelial cells when they areinduced to form tubes in vitro. Transgenic overexpression in NIH3T3 cells causesup­regulation of proteins such as VEGF and FGF basic, and increases cell growthrate and tumorigenicity. DMC and two other chemokines that play roles in angiogenesis,CXCL1/GRO and CXCL8/IL­8, show significantly correlated expression with that ofVEGF in primary lung, breast and esophageal tumors. DMC is therefore suggestedto play a role in tumor angiogenesis. Mature human DMC shares 73%, 71% and 64%amino acid sequence identity with bovine, mouse and rat DMC, respectively.
Source : E. coli­derived
Form : Lyophilized from a 0.2μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
N-terminal Sequence : Leu24
Molecular Weight : 11.3 kDa
Activity : Measured by its abilityto induce VEGF expression in mouse endothelial cells. The ED50 for this effectis typically 1 ­ 5 µg/mL.
Purity : >95%, by SDS­PAGEunder reducing conditions and visualized by silver stain.
Endotoxin Level : <1.0 EU per 1 μg ofthe protein by the LAL method.
Reconstitution : Reconstitute at 100μg/mL in PBS that containing at least 0.1% human or bovine serum albumin.
Storage : Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
OfficialSymbol : CXCL17
Gene Name : CXCL17 chemokine (C-X-C motif)ligand 17 [ Homo sapiens ]
Synonyms : CXCL17; chemokine (C-X-Cmotif) ligand 17; DMC; VCC1; Dcip1; VCC-1; UNQ473; MGC138300; VEGF co-regulatedchemokine 1; C-X-C motif chemokine 17; dendritic cell and monocyte chemokine-likeprotein
Gene ID : 284340
mRNA Refseq : NM_198477
Protein Refseq : NP_940879
MIM : 611387
UniProt ID : Q6UXB2
Chromosome Location : 19q13.2
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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