Active Recombinant Human CLEC12A Protein (Thr67-Ala265), N-hFc tagged

• Cat.No.: CLEC12A-50H
• Product Overview: Recombinant Human MICL/CLEC12A Protein ((Thr67-Ala265)) with a Human IgG1 (Pro100-Lys330) Fc tag at N-terminus was expressed in Chinese Hamster Ovary cell line.

Specification

• Description: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.
• Source: CHO
• Species: Human
• Tag: N-hFc
• Form: Disulfide-linked homodimer
• Bio-activity: Measured by its binding ability in a functional ELISA. When Recombinant Human Integrin alpha X beta 2 Protein is immobilized at 5.00 μg/mL, 100 μL/well, the concentration of Recombinant Human MICL/CLEC12A Fc Chimera that produces 50% of the optimal binding response is approximately 1.20-12.0 μg/mL.
• Molecular Mass: Predicted Molecular Mass: 50 kDa
  SDS-PAGE: 70-85 kDa, under reducing conditions
• Protein Length: Thr67-Ala265
• N-terminal Sequence Analysis: Met
• Endotoxin: < 0.10 EU/μg of the protein by the LAL method.
• Purity: > 90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 centigrade as supplied.
  1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
  3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
• Reconstitution: Reconstitute at 500 μg/mL in PBS.
• Shipping: The product is shipped at ambient temperature.

Gene Information

• Gene Name: CLEC12A C-type lectin domain family 12 member A [ Homo sapiens (human) ]
• Official Symbol: CLEC12A
• Synonyms: CLEC12A; C-type lectin domain family 12 member A; CLL1; MICL; CD371; CLL-1; DCAL-2; C-type lectin domain family 12 member A; C-type lectin protein CLL-1; C-type lectin-like molecule-1; dendritic cell-associated lectin 2; myeloid inhibitory C-type lectin-like receptor
• Gene ID: 160364
• mRNA Refseq: NM_201623
• Protein Refseq: NP_963917
• MIM: 612088
• UniProt ID: Q5QGZ9