Active Recombinant Human CLK3 Protein, GST-tagged

• Cat.No.: CLK3-1496H
• Product Overview: Human CLK3 (AAH02555.1, 1 a.a. - 490 a.a.) full-length recombinant protein with GST tag expressed in Baculovirus infected Sf21 cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Description: This gene encodes a protein belonging to the serine/threonine type protein kinase family. This protein is a nuclear dual-specificity kinase that regulates the intranuclear distribution of the serine/arginine-rich (SR) family of splicing factors. Two transcript variants encoding different isoforms have been found for this gene. Related pseudogenes are located on chromosomes 1 and 9. [provided by RefSeq, Jul 2008]
• Form: Liquid
• Bio-activity: The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorescence-labeled substrate and Mg (or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip™3000.Substrate : DYRKtide-F. ATP: 100 µM.
• Molecular Mass: 86 kDa
• Purity: 88 % by SDS-PAGE/CBB staining.
• Applications: Functional Study
  SDS-PAGE
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.05% Brij35, 1 mM DTT, 10% glycerol)

Gene Information

• Gene Name: CLK3 CDC-like kinase 3 [ Homo sapiens ]
• Official Symbol: CLK3
• Synonyms: CLK3; CDC-like kinase 3; dual specificity protein kinase CLK3; clk3; PHCLK3; PHCLK3/152; FLJ22858
• Gene ID: 1198
• mRNA Refseq: NM_001130028
• Protein Refseq: NP_001123500
• MIM: 602990
• UniProt ID: P49761