Active Recombinant Human ENPP2, His-tagged
| Cat.No. : | ENPP2-3123H |
| Product Overview : | Recombinant human ENPP2/ATX (ectonucleotide pyrophosphatase-phosphodiesterase 2) is a single polypeptide chain with a 8His tag at the C-terminus. It contains 925 (915+10) amino acids, and having a predicted molecular mass of approximately 106.4kD and migrates in SDS-PAGE with an apparent molecular mass of 110kD. |
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| Species : | Human |
| Source : | HEK293 |
| Tag : | His |
| Description : | Autotaxin also known as ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (E-NPP 2) is an enzyme that in humans is encoded by the ENPP2 gene. |
| Form : | 20mM Tris-Cl (pH7.9), 20% Glycerol, 100mM NaCl, 1mM DTT and 0.5mM EDTA |
| Bio-activity : | ENPP2 protein stimulates the motility of tumor cells with angiogenic properties. It functions as a phosphodiesterase to cleave phosphodiester bonds and a phospholipase to catalyze production of lysophosphatidic acid (LPA). Recombinant human ENPP2 protein is ideal for the studies of its enzyme activity and other related function assays |
| AA Sequence : | MARRSSFQSCQIISLFTFAVGVNICLGFTAHRIKRAEGWEEGPPTVLSDSPWTNISGSCKGRCFELQEAGPPDC RCDNLCKSYTSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLARGDCCTNYQVVCKGESHWVDDD CEEIKAAECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGL YPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVKAGTFFWSVVIPHERRILTILQWLTL PDHERPSVYAFYSEQPDFSGHKYGPFGPEESSYGSPFTPAKRPKRKVAPKRRQERPVAPPKKRRRKIHRMDHY AAETRQDKMTNPLREIDKIVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTL GRIRSKFSNNAKYDPKAIIANLTCKKPDQHFKPYLKQHLPKRLHYANNRRIEDIHLLVERRWHVARKPLDVYK KPSGKCFFQGDHGFDNKVNSMQTVFVGYGSTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRT NTFRPTMPEEVTRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLDELNKRLHTKGSTEERHLLYGRPAVLYRTRY DILYHTDFESGYSEIFLMPLWTSYTVSKQAEVSSVPDHLTSCVRPDVRVSPSFSQNCLAYKNDKQMSYGFLFPP YLSSSPEAKYDAFLVTNMVPMYPAFKRVWNYFQRVLVKKYASERNGVNVISGPIFDYDYDGLHDTEDKIKQYV EGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNEESCNSSEDESKWVEELMKMHTARVRDIE HLTSLDFFRKTSRSYPEILTLKTYLHTYESEIGGHHHHHHHH |
| Purity : | ≥90%, as determined by SDS-PAGE |
| Usage : | FOR RESEARCH ONLY |
| Storage : | The protein sample can be stored under sterile conditions at 2- 8 centigrade for one month or at -70 centigrade for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles. |
| Gene Name | ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 [ Homo sapiens ] |
| Official Symbol | ENPP2 |
| Synonyms | ATX; NPP2; ATX-X; PDNP2; LysoPLD; AUTOTAXIN; PD-IALPHA; ectonucleotide pyrophosphatase/phosphodiesterase family member 2; E-NPP 2; autotaxin-t; extracellular lysophospholipase D; phosphodiesterase I/nucleotide pyrophosphatase 2; plasma lysophospholipase D |
| Gene ID | 5168 |
| mRNA Refseq | NM_001040092 |
| Protein Refseq | NP_001035181 |
| MIM | 601060 |
| UniProt ID | Q13822 |
| Chromosome Location | 8q24.1 |
| Pathway | Ether lipid metabolism, organism-specific biosystem; Ether lipid metabolism, conserved biosystem |
| Function | alkylglycerophosphoethanolamine phosphodiesterase activity; calcium ion binding; hydrolase activity |
Not For Human Consumption!
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