Active Recombinant Human Fc Receptor-Like B, His-tagged

• Cat.No.: FCRLB-512H
• Product Overview: RecombinantHuman FCRLB protein was expressed in Murine myeloma cellline. Ala18-Ser426,with a C-terminal 6-His tag.

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: His
• Protein Length: 18-426 a.a.
• Description: FCRLB isa 60 kDa protein with sequence homology to classical Fc receptors. There areat least six type 1 transmembrane FCRL proteins and two that lack transmembranesegments. Each family member contains between three and nine immunoglobulin-likedomains. FCRL proteins are differentially expressed within the B cell lineageand can either promote or inhibit B cell proliferation and activation. Accordingto R&D Systems testing, FCRLB binds to purified human IgG with highaffinity. Human FCRLB shares 82% and 85% amino acid sequence identity withmouse and rat FCRLB, respectively. It contains a putative signal peptide,three immunoglobulin-like domains, and a mucinlike stalk that is rich in Pro,Ser, and Thr residues.
• Form: Lyophilized from a0.2 um filtered solution in PBS and EDTA.
• N-terminalSequence: Ala18
• MolecularWeight: 46 kDa
• Activity: Measuredby its ability to bind human IgG with an estimated KD < 120 nM.
• Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
• SDS-PAGE: 65-70kDa, reducing conditions.
• Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: Reconstitute at 100μg/mLin PBS.
• Storage: Use amanual defrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3months, -20 to -70°C under sterile conditions after reconstitution.

Gene Information

• Gene Name: FCRLB Fc receptor-like B [ Homosapiens ]
• Official Symbol: FCRLB
• Synonyms: FCRLB; Fc receptor-like B; Fc receptorlike and mucin like 2; FCRLM2; FCRL2; FCRLY; FLJ31052; FREB2; RP11-474I16.6;Fc receptor homolog expressed in B cells protein 2; Fc receptor like B; Fcreceptor like mucin like 2; Fc receptor like protein 2; Fc receptor relatedY; Fcry; mFCRL2; RGD1563018; fc receptor-like and mucin-like protein 2; FcRY;FREB-2
• Gene ID: 127943
• mRNA Refseq: NM_001002901
• Protein Refseq: NP_001002901
• MIM: 609251
• UniProt ID: Q6BAA4
• Chromosome Location: 1q23.3